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Literature DB >> 1502268

Interphotoreceptor retinoid-binding protein and alpha-tocopherol preserve the isomeric and oxidation state of retinol.

R K Crouch¹, E S Hazard, T Lind, B Wiggert, G Chader, D W Corson.

Abstract

Retinol decomposes rapidly into a number of products, including its aldehyde form, retinal, when introduced into buffer in phospholipid vesicles or ethanol. Interphotoreceptor retinoid-binding protein at low concentrations is found to protect retinol from isomerization and oxidation. The addition of alpha-tocopherol to either liposomes or an ethanolic-buffer solution also prevents decomposition. Neither of these agents interferes with the successful regeneration of pigment with 9-cis retinal in rod outer segment preparations or the restoration of sensitivity by retinoids in isolated rod photoreceptors.

Entities: Chemical

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Year: 1992 PMID： 1502268 DOI： 10.1111/j.1751-1097.1992.tb02154.x

Source DB: PubMed Journal: Photochem Photobiol ISSN： 0031-8655 Impact factor: 3.421

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Cited

35 in total

Review 1. Retinoid-binding proteins: mediators of retinoid action.

Authors: N Noy
Journal: Biochem J Date: 2000-06-15 Impact factor: 3.857

2. Interphotoreceptor retinoid-binding protein gene structure in tetrapods and teleost fish.

Authors: John M Nickerson; Ruth A Frey; Vincent T Ciavatta; Deborah L Stenkamp
Journal: Mol Vis Date: 2006-12-09 Impact factor: 2.367

3. Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.

Authors: Kota Sato; Songhua Li; William C Gordon; Jibao He; Gregory I Liou; James M Hill; Gabriel H Travis; Nicolas G Bazan; Minghao Jin
Journal: J Neurosci Date: 2013-10-30 Impact factor: 6.167

4. Interphotoreceptor retinoid-binding protein protects retinoids from photodegradation.

Authors: Federico Gonzalez-Fernandez; Brandi Betts-Obregon; Brian Yust; Joshua Mimun; Dongjin Sung; Dhiraj Sardar; Andrew T Tsin
Journal: Photochem Photobiol Date: 2015-02-10 Impact factor: 3.421

5. The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein.

Authors: Alexander V Kolesnikov; Peter H Tang; Ryan O Parker; Rosalie K Crouch; Vladimir J Kefalov
Journal: J Neurosci Date: 2011-05-25 Impact factor: 6.167

Interphotoreceptor retinoid-binding protein and alpha-tocopherol preserve the isomeric and oxidation state of retinol.

Review 1. Retinoid-binding proteins: mediators of retinoid action.

2. Interphotoreceptor retinoid-binding protein gene structure in tetrapods and teleost fish.

3. Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.

4. Interphotoreceptor retinoid-binding protein protects retinoids from photodegradation.

5. The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein.

6. A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa.

7. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo.

8. Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity.

Review 9. New insights into retinoid metabolism and cycling within the retina.

10. Normal cone function requires the interphotoreceptor retinoid binding protein.