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Literature DB >> 15022176

Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum.

Abstract

Four sesquiterpene lactones of the pseudo-guaianolide type (helenalin, dihydrohelenalin and their acetates), have shown activities against asexual blood forms of Plasmodium falciparum in vitro. Their IC(50) values were situated in the range of 0.23 to 7.41 micro M. The activity found for helenalin was high, even compared to the activity found for artemisinin. Copyright 2004 John Wiley & Sons, Ltd.

Entities: Chemical Disease Species

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Year: 2004 PMID： 15022176 DOI： 10.1002/ptr.1376

Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878

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Cited

5 in total

1. NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death.

Authors: Chuan Bian Lim; Pan You Fu; Nung Ky; Hong Shuang Zhu; XiaoLing Feng; Jinming Li; Kandhadayar Gopalan Srinivasan; Mohamed Sabry Hamza; Yan Zhao
Journal: BMC Complement Altern Med Date: 2012-07-11 Impact factor: 3.659

2. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling.

Authors: John V W Becker; Marina M van der Merwe; Anna C van Brummelen; Pamisha Pillay; Bridget G Crampton; Edwin M Mmutlane; Chris Parkinson; Fanie R van Heerden; Neil R Crouch; Peter J Smith; Dalu T Mancama; Vinesh J Maharaj
Journal: Malar J Date: 2011-10-11 Impact factor: 2.979

Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum.

1. NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death.

2. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling.

3. QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits.

Review 4. Biological Activity of Selected Natural and Synthetic Terpenoid Lactones.

Review 5. Applications of ultrasound in total synthesis of bioactive natural products: A promising green tool.