Sweet dreams?--nocturnal hypoglycemia in children with type 1 diabetes.

Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose homeostasis during fasting, delayed effects of exercise and alterations in sleep physiology, itself, may not only affect the risk of nocturnal hypoglycemia but may influence the ability to correct glucose concentration as it falls, leading to episodes of hypoglycemia which are both profound and prolonged. The etiology and potential repercussions are incompletely understood and the most appropriate defense remains unclear. A greater understanding of this enigmatic phenomenon is essential before appropriate methods for hypoglycemia avoidance can be developed.