Literature DB >> 15013410

A novel alpha-glucosidase inhibitor from pine bark.

Yong-Mu Kim1, Myeong-Hyeon Wang, Hae-Ik Rhee.   

Abstract

Inhibitors of carbohydrate-hydrolysing enzymes play an important role for the treatment of diabetes. To our knowledge, a number of inhibitors such as, 1-deoxynojirimycin, acarbose and voglibose have been identified as a result of screening of secondary metabolites up to now. In this note, we report the inhibitory effect on carbohydrate hydrolysis of ethanol extracts from more than 1400 species of plants with the aim of identifying a potential antihyperglycemic drug. Pinus densiflora bark extracts showed the highest inhibition activity against several carbohydrate-hydrolysing enzymes.

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Year:  2004        PMID: 15013410     DOI: 10.1016/j.carres.2003.11.005

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN: 0008-6215            Impact factor:   2.104


  34 in total

1.  Capillary electrophoresis as a screening tool for alpha amylase inhibitors in plant extracts.

Authors:  Imad I Hamdan; Fatima U Afifi
Journal:  Saudi Pharm J       Date:  2010-02-13       Impact factor: 4.330

2.  Assessment of anti-diabetic activity of peanut shell polyphenol extracts.

Authors:  Xiao-Meng Sun; Hai-Qing Ye; Jing-Bo Liu; Lei Wu; Ding-Bo Lin; Ya-Li Yu; Feng Gao
Journal:  J Zhejiang Univ Sci B       Date:  2018 Oct.       Impact factor: 3.066

3.  Isolation, identification, and potential probiotic characterization of isolated lactic acid bacteria and in vitro investigation of the cytotoxicity, antioxidant, and antidiabetic activities in fermented sausage.

Authors:  Nadia S AlKalbani; Mark S Turner; Mutamed M Ayyash
Journal:  Microb Cell Fact       Date:  2019-11-05       Impact factor: 5.328

4.  Synthesis, spectral analysis, DFT calculations, biological potential and molecular docking studies of indole appended pyrazolo-triazine.

Authors:  S M Basavarajaiah; G Y Nagesh; Mohammad Javeed; Rashmi Bhat; S Nethravathi; Jeelan N Basha; K Ramakrishna Reddy; C Nisarga; Pooja Srinivas
Journal:  Mol Divers       Date:  2022-05-10       Impact factor: 2.943

5.  Hypoglycemic activity of Pyrus biossieriana Buhse leaf extract and arbutin: Inhibitory effects on alpha amylase and alpha glucosidase.

Authors:  Fatemeh Yousefi; Soleiman Mahjoub; Mahdi Pouramir; Fatemeh Khadir
Journal:  Caspian J Intern Med       Date:  2013

6.  In vitro study on the antioxidant activity of a polyphenol-rich extract from Pinus brutia bark and its fractions.

Authors:  Elena Cretu; Maarit Karonen; Juha-Pekka Salminen; Cornelia Mircea; Adriana Trifan; Christiana Charalambous; Andreas I Constantinou; Anca Miron
Journal:  J Med Food       Date:  2013-11-06       Impact factor: 2.786

7.  Degradation capacities of bacteria and yeasts isolated from the gut of Dendroctonus rhizophagus (Curculionidae: Scolytinae).

Authors:  Carlos I Briones-Roblero; Roberto Rodríguez-Díaz; José A Santiago-Cruz; Gerardo Zúñiga; Flor N Rivera-Orduña
Journal:  Folia Microbiol (Praha)       Date:  2016-08-20       Impact factor: 2.099

8.  A novel α-glucosidase inhibitory constituent from Uncaria gambir.

Authors:  Tae Hoon Kim
Journal:  J Nat Med       Date:  2016-06-04       Impact factor: 2.343

9.  Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions.

Authors:  Hasni Misbah; Azlina Abdul Aziz; Norhaniza Aminudin
Journal:  BMC Complement Altern Med       Date:  2013-05-29       Impact factor: 3.659

Review 10.  [Inhibitors of alpha-amylase from plants--a possibility to treat diabetes mellitus type II by phytotherapy?].

Authors:  Matthias F Melzig; Ines Funke
Journal:  Wien Med Wochenschr       Date:  2007
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