| Literature DB >> 15013022 |
Robin D Clark1, Alam Jahangir, Daniel Severance, Rick Salazar, Thomas Chang, David Chang, Mary Frances Jett, Steven Smith, Keith Bley.
Abstract
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity in the rat.Entities:
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Year: 2004 PMID： 15013022 DOI： 10.1016/j.bmcl.2003.10.070
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823