STUDY OBJECTIVE: We sought a marker to differentiate tuberculous pleural effusions from nontuberculous pleural effusions, which otherwise can be difficult. PATIENTS: We studied 55 patients with pleural effusions, 20 (36%) with tuberculous pleuritis and 35 (64%) with a nontuberculous etiology. MEASUREMENTS AND RESULTS: Pleural fluid levels of adenosine deaminase, interferon (INF)-gamma, interleukin (IL)-12p40, IL-18, immunosuppressive acidic protein, and soluble IL-2 receptors were measured and were subjected to receiver operating characteristic analysis. INF-gamma had the greatest sensitivity and specificity for tuberculous pleuritis among the six biological markers studied. CONCLUSION: The determination of INF-gamma levels in pleural fluid is the most informative in the diagnosis of tuberculous effusion.
STUDY OBJECTIVE: We sought a marker to differentiate tuberculous pleural effusions from nontuberculous pleural effusions, which otherwise can be difficult. PATIENTS: We studied 55 patients with pleural effusions, 20 (36%) with tuberculous pleuritis and 35 (64%) with a nontuberculous etiology. MEASUREMENTS AND RESULTS:Pleural fluid levels of adenosine deaminase, interferon (INF)-gamma, interleukin (IL)-12p40, IL-18, immunosuppressive acidic protein, and soluble IL-2 receptors were measured and were subjected to receiver operating characteristic analysis. INF-gamma had the greatest sensitivity and specificity for tuberculous pleuritis among the six biological markers studied. CONCLUSION: The determination of INF-gamma levels in pleural fluid is the most informative in the diagnosis of tuberculous effusion.
Authors: Rafael San Juan; Carmen Sánchez-Suárez; María J Rebollo; Dolores Folgueira; Elia Palenque; Blanca Ortuño; Carlos Lumbreras; José M Aguado Journal: J Neurol Date: 2006-06-19 Impact factor: 4.849
Authors: Fahmi Yousef Khan; Maha Hamza; Aisha Hussein Omran; Muhannad Saleh; Mona Lingawi; Adel Alnaqdy; Mohamed Osman Abdel Rahman; Hasan Syed Ahmedullah; Alan Hamza; Ahmed Al Ani; Mehdi Errayes; Mona Almaslamani; Ahmed Ali Mahmood Journal: Int J Gen Med Date: 2013-01-10