Literature DB >> 15006398

Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480.

Gianluca Sbardella1, Antonello Mai, Marino Artico, Roberta Loddo, Maria Grazia Setzu, Paolo La Colla.   

Abstract

Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).

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Year:  2004        PMID： 15006398     DOI： 10.1016/j.bmcl.2004.01.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.

Authors:  J W C Alffenaar; T van der Laan; S Simons; T S van der Werf; P J van de Kasteele; H de Neeling; D van Soolingen
Journal:  Antimicrob Agents Chemother       Date:  2011-01-03       Impact factor: 5.191

2.  Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.

Authors:  Shu Liu; Padmavathy Nandha Premnath; Joshua K Bolger; Tracy L Perkins; Lindsay O Kirkland; George Kontopidis; Campbell McInnes
Journal:  J Med Chem       Date:  2013-02-12       Impact factor: 7.446

3.  1H-Pyrrole-2-carbohydrazide.

Authors:  Lina Wang; Xiangrong Liu; Chun Yang; Shunsheng Zhao; Kanshe Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-26

4.  In Vitro Activities of LCB 01-0648, a Novel Oxazolidinone, against Gram-Positive Bacteria.

Authors:  Sang-Hun Oh; Josep Kim; Sung-Yoon Baek; Sang-Eun Chae; Hee-Soo Park; Young-Lag Cho; Jin-Hwan Kwak
Journal:  Molecules       Date:  2017-03-03       Impact factor: 4.411

5.  Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.

Authors:  Hakan Bektaş; Nesrin Karaali; Deniz Sahin; Ahmet Demirbaş; Sengül Alpay Karaoglu; Neslihan Demirbaş
Journal:  Molecules       Date:  2010-04-08       Impact factor: 4.411

6.  Synthesis and Biological Evaluation of 3-(Pyridine-3-yl)-2-Oxazolidinone Derivatives as Antibacterial Agents.

Authors:  Bo Jin; Tong Wang; Jia-Yi Chen; Xiao-Qing Liu; Yi-Xin Zhang; Xiu-Ying Zhang; Zun-Lai Sheng; Hong-Liang Yang
Journal:  Front Chem       Date:  2022-07-18       Impact factor: 5.545

7.  Discovery and optimisation studies of antimalarial phenotypic hits.

Authors:  Alka Mital; Dinakaran Murugesan; Marcel Kaiser; Clive Yeates; Ian H Gilbert
Journal:  Eur J Med Chem       Date:  2015-09-09       Impact factor: 6.514
  7 in total

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