Literature DB >> 15006381

Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-beta.

Baoqing Gong1, Feng Hong, Cory Kohm, Lynn Bonham, Peter Klein.   

Abstract

2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.

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Year:  2004        PMID： 15006381     DOI： 10.1016/j.bmcl.2004.01.023

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Chemical modulation of glycerolipid signaling and metabolic pathways.

Authors:  Sarah A Scott; Thomas P Mathews; Pavlina T Ivanova; Craig W Lindsley; H Alex Brown
Journal:  Biochim Biophys Acta       Date:  2014-01-15

2.  Diversity-oriented synthesis of benzimidazole, benzoxazole, benzothiazole and quinazolin-4(3H)-one libraries via potassium persulfate-CuSO4-mediated oxidative coupling reactions of aldehydes in aqueous micelles.

Authors:  Atul Kumar; Ram Awatar Maurya; Deepti Saxena
Journal:  Mol Divers       Date:  2009-07-04       Impact factor: 2.943

3.  Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity.

Authors:  Corina Cheptea; Valeriu Sunel; Ana Cezarina Morosanu; Dan Gheorghe Dimitriu; Mihaela Maria Dulcescu-Oprea; Mihai-Daniel Angheluta; Mihaela Miron; Cristina Delia Nechifor; Dana Ortansa Dorohoi; Razvan Nicolae Malancus
Journal:  Biomedicines       Date:  2021-04-26

4.  Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives.

Authors:  Bassem Sadek; Moawia Mohammad Al-Tabakha; Khairi Mustafa Salem Fahelelbom
Journal:  Molecules       Date:  2011-11-09       Impact factor: 4.411

5.  (2E)-2-(1,3-Benzo-thia-zol-2-yl)-3-(di-methyl-amino)-prop-2-ene-nitrile.

Authors:  Shaaban K Mohamed; Mehmet Akkurt; Benson M Kariuki; Ali M Ali; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-12-14

6.  Skin Damages-Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System.

Authors:  Ernestine Nicaise Djuidje; Elisa Durini; Sabrina Sciabica; Elena Serra; Jan Balzarini; Sandra Liekens; Stefano Manfredini; Silvia Vertuani; Anna Baldisserotto
Journal:  Molecules       Date:  2020-09-21       Impact factor: 4.411
  6 in total

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