| Literature DB >> 15006369 |
Michael J Bowman1, Jean Chmielewski.
Abstract
An inhibitor based on crosslinked peptides from the interfacial region of HIV-1 protease, previously shown to act by dimerization inhibition, was modified by N-methylation to ascertain the importance of the amide hydrogens on inhibition. The effects of N-methylation on HIV-1 protease inhibition, as well as the effects on degradation by proteases are described.Entities:
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Year: 2004 PMID： 15006369 DOI： 10.1016/j.bmcl.2003.09.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823