| Literature DB >> 15004331 |
Joseph F Quinn1, Kathleen S Montine, Milar Moore, Jason D Morrow, Jeffrey A Kaye, Thomas J Montine.
Abstract
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.Entities:
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Year: 2004 PMID: 15004331 DOI: 10.3233/jad-2004-6110
Source DB: PubMed Journal: J Alzheimers Dis ISSN: 1387-2877 Impact factor: 4.472