| Literature DB >> 15003419 |
Aslieh Nookandeh1, Norbert Frank, Frank Steiner, Renate Ellinger, Bernd Schneider, Clarissa Gerhäuser, Hans Becker.
Abstract
Xanthohumol (1), isolated from hop, was fed to rats in a dose of 1000 mg kg(-1) body weight. The faeces of the animals were collected after 24 and 48 h and analysed for metabolites of 1. Approximately 89% of the recovered flavonoid-compounds consisted of unchanged 1. Sixteen metabolites and six previously known metabolites were isolated and characterized by coupling techniques (HPLC-NMR, HPLC-MS and HPLC-DAD). Their structures were elucidated by spectroscopic methods, especially using NMR spectroscopy. Twenty metabolites had a modified chalcone structure and two metabolites were flavanone derivatives.Entities:
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Year: 2004 PMID： 15003419 DOI： 10.1016/j.phytochem.2003.11.016
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072