Shinji Hirai1. 1. Department of Thoracic and Cardiovascular Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Abstract
OBJECTIVE: This prospective study was designed to elucidate the duration of systemic inflammatory response syndrome (SIRS) and the mechanisms that lead to the protraction of SIRS in patients who are operated on under cardiopulmonary bypass (CPB). METHODS: The duration of SIRS in 13 patients with SIRS was studied. Two groups were divided according to the duration to investigate the meaning of the duration of SIRS. The perioperative parameters which significantly correlated with the duration of SIRS, including the kinetics of cytokines and white blood cells (WBC) counts were investigated. RESULTS: In patients with SIRS extending for a period greater than 12 hours (group A), the duration of CPB, interleukin-6 (IL-6), interleukin-8 (IL-8) and WBC count after aortic declamping were significantly longer and higher than those in patients with SIRS lasting less than 12 hours (group B). The duration of SIRS significantly correlated with the highest level of IL-6 (r=0.724, p=0.0038) and the duration of CPB (r=0.626, p=0.0201). CONCLUSIONS: These results suggest that the duration of CPB and cytokinemia, with high IL-6 levels, during this short time frame until just after cardiac surgery might play an important role in the development of the SIRS.
OBJECTIVE: This prospective study was designed to elucidate the duration of systemic inflammatory response syndrome (SIRS) and the mechanisms that lead to the protraction of SIRS in patients who are operated on under cardiopulmonary bypass (CPB). METHODS: The duration of SIRS in 13 patients with SIRS was studied. Two groups were divided according to the duration to investigate the meaning of the duration of SIRS. The perioperative parameters which significantly correlated with the duration of SIRS, including the kinetics of cytokines and white blood cells (WBC) counts were investigated. RESULTS: In patients with SIRS extending for a period greater than 12 hours (group A), the duration of CPB, interleukin-6 (IL-6), interleukin-8 (IL-8) and WBC count after aortic declamping were significantly longer and higher than those in patients with SIRS lasting less than 12 hours (group B). The duration of SIRS significantly correlated with the highest level of IL-6 (r=0.724, p=0.0038) and the duration of CPB (r=0.626, p=0.0201). CONCLUSIONS: These results suggest that the duration of CPB and cytokinemia, with high IL-6 levels, during this short time frame until just after cardiac surgery might play an important role in the development of the SIRS.
Authors: Luis A Socha; John Gowardman; Diego Silva; Manuel Correcha; Nikolai Petrosky Journal: Intensive Care Med Date: 2006-01-26 Impact factor: 17.440
Authors: Jill M Cholette; Kelly F Henrichs; George M Alfieris; Karen S Powers; Richard Phipps; Sherry L Spinelli; Michael Swartz; Francisco Gensini; L Eugene Daugherty; Emily Nazarian; Jeffrey S Rubenstein; Dawn Sweeney; Michael Eaton; Norma B Lerner; Neil Blumberg Journal: Pediatr Crit Care Med Date: 2012-05 Impact factor: 3.624
Authors: Joo Han Song; Won Ki Woo; Seung Hwan Song; Hyo Hyun Kim; Bong Joon Kim; Ha Eun Kim; Do Jung Kim; Jee Won Suh; Yu Rim Shin; Han Ki Park; Seung Hyun Lee; Hyun Chel Joo; Sak Lee; Byung Chul Chang; Kyung Jong Yoo; Young Sam Kim; Young Nam Youn Journal: J Thorac Dis Date: 2016-07 Impact factor: 2.895
Authors: John C Greenwood; David H Jang; Stephen D Hallisey; Jacob T Gutsche; Jiri Horak; Michael A Acker; Christian A Bermudez; Victoria L Zhou; Shampa Chatterjee; Frances S Shofer; Todd J Kilbaugh; John G T Augoustides; Nuala J Meyer; Jan Bakker; Benjamin S Abella Journal: J Cardiothorac Vasc Anesth Date: 2020-05-14 Impact factor: 2.628
Authors: Shukri F Khuri; William G Henderson; Ralph G DePalma; Cecilia Mosca; Nancy A Healey; Dharam J Kumbhani Journal: Ann Surg Date: 2005-09 Impact factor: 12.969
Authors: Amy E Schmidt; Emily Gore; Kelly F Henrichs; Grace Conley; Charles Dorsey; Kimberly B Bjugstad; Majed A Refaai; Neil Blumberg; Jill M Cholette Journal: Pediatr Cardiol Date: 2017-10-31 Impact factor: 1.655