Luis A Socha1, John Gowardman2,3, Diego Silva1, Manuel Correcha1, Nikolai Petrosky4. 1. John Curtin School of Medical Research, Australian National University, ACT 2601, Canberra, Australia. 2. Intensive Care Unit, Launceston General Hospital, TAS 7250, Launceston, Australia. john.gowardman@dhhs.tas.gov.au. 3. Intensive Care Unit, Canberra Hospital, ACT 2605, Canberra, Australia. john.gowardman@dhhs.tas.gov.au. 4. Department of Endocrinology, Flinders Medical Centre, SA 5042, Adelaide, Australia.
Abstract
OBJECTIVE: To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (TNF) alpha and total serum cortisol in the systemic inflammatory response syndrome (SIRS). DESIGN AND SETTING: Prospective observational study in a 12-bed medical-surgical ICU of a 500-bed university hospital. PATIENTS: Ten patients with SIRS and eight controls. MEASUREMENTS: Arterial blood was sampled hourly for 24 h for measurement of plasma IL-13, TNF- alpha, cortisol and white blood cell count (WCC) differential within 24 h of development of SIRS. RESULTS: There were significantly higher plasma IL-13 levels in SIRS patients than in controls (1282 vs. 713 pg/ml). IL-13 was significantly higher in patients with a diagnosis of sepsis than in those with non-infectious causes of SIRS (2080 vs. 515 pg/ml). In SIRS the elevation in IL-13 was associated with higher TNF-alpha and reduced WCC. A circadian rhythm was observed in plasma IL-13 secretion. No distinct circadian rhythm was noted for TNF- alpha, and the normal circadian rhythm of serum cortisol was lost. CONCLUSIONS: The anti-inflammatory cytokine IL-13 is elevated in early SIRS. Its plasma level exhibits a circadian rhythm and may be modulated in part by TNF-alpha. SIRS patients have disruption of the normal circadian rhythm of serum cortisol.
OBJECTIVE: To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (TNF) alpha and total serum cortisol in the systemic inflammatory response syndrome (SIRS). DESIGN AND SETTING: Prospective observational study in a 12-bed medical-surgical ICU of a 500-bed university hospital. PATIENTS: Ten patients with SIRS and eight controls. MEASUREMENTS: Arterial blood was sampled hourly for 24 h for measurement of plasma IL-13, TNF- alpha, cortisol and white blood cell count (WCC) differential within 24 h of development of SIRS. RESULTS: There were significantly higher plasma IL-13 levels in SIRS patients than in controls (1282 vs. 713 pg/ml). IL-13 was significantly higher in patients with a diagnosis of sepsis than in those with non-infectious causes of SIRS (2080 vs. 515 pg/ml). In SIRS the elevation in IL-13 was associated with higher TNF-alpha and reduced WCC. A circadian rhythm was observed in plasma IL-13 secretion. No distinct circadian rhythm was noted for TNF- alpha, and the normal circadian rhythm of serum cortisol was lost. CONCLUSIONS: The anti-inflammatory cytokine IL-13 is elevated in early SIRS. Its plasma level exhibits a circadian rhythm and may be modulated in part by TNF-alpha. SIRS patients have disruption of the normal circadian rhythm of serum cortisol.
Authors: M Rodríguez-Gaspar; F Santolaria; A Jarque-López; E González-Reimers; A Milena; M J de la Vega; E Rodríguez-Rodríguez; J L Gómez-Sirvent Journal: Cytokine Date: 2001-08-21 Impact factor: 3.861
Authors: S R Bornstein; J Licinio; R Tauchnitz; L Engelmann; A B Negrão; P Gold; G P Chrousos Journal: J Clin Endocrinol Metab Date: 1998-01 Impact factor: 5.958
Authors: J M Baumhofer; B G Beinhauer; J E Wang; H Brandmeier; K Geissler; U Losert; R Philip; G Aversa; M A Rogy Journal: Eur J Immunol Date: 1998-02 Impact factor: 5.532
Authors: D Torre; R Tambini; S Aristodemo; G Gavazzeni; A Goglio; C Cantamessa; A Pugliese; G Biondi Journal: Mediators Inflamm Date: 2000 Impact factor: 4.711
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel De Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard Journal: Intensive Care Med Date: 2006-12-19 Impact factor: 17.440
Authors: Inbal Rachmin; Caitlin C O'Meara; Elisabeth M Ricci-Blair; Yilin Feng; Emily M Christensen; Jeanne F Duffy; Kirsi M Zitting; Charles A Czeisler; James R Pancoast; Christopher P Cannon; Michelle L O'Donoghue; David A Morrow; Richard T Lee Journal: Am J Physiol Endocrinol Metab Date: 2017-09-05 Impact factor: 4.310
Authors: Roberto Romero; Piya Chaemsaithong; Nikolina Docheva; Steven J Korzeniewski; Adi L Tarca; Gaurav Bhatti; Zhonghui Xu; Juan P Kusanovic; Noppadol Chaiyasit; Zhong Dong; Bo Hyun Yoon; Sonia S Hassan; Tinnakorn Chaiworapongsa; Lami Yeo; Yeon Mee Kim Journal: J Perinat Med Date: 2016-01 Impact factor: 1.901