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Literature DB >> 15001815

Genes associated with addiction: alcoholism, opiate, and cocaine addiction.

Mary Jeanne Kreek¹, David A Nielsen, K Steven LaForge.

Abstract

Drug addiction is a complex disorder that has a large spectrum of causes. Vulnerability to addiction has been shown in twin studies to have a robust genetic component. This genetic basis for addiction has general and specific components for each drug abused. Although many genes have been implicated in drug addiction, only a handful have either been replicated to have an association or to have an identified functional mechanism related to specific effects of abused drugs. A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article.

Entities: Chemical Disease

Mesh：

Year: 2004 PMID： 15001815 DOI： 10.1385/NMM:5:1:085

Source DB: PubMed Journal: Neuromolecular Med ISSN： 1535-1084 Impact factor: 3.843

166 in total

1. Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.

Authors: J Gelernter; H Kranzler; J Cubells
Journal: Mol Psychiatry Date: 1999-09 Impact factor: 15.992

2. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.

Authors: D A Nielsen; M Dean; D Goldman
Journal: Am J Hum Genet Date: 1992-12 Impact factor: 11.025

3. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

Authors: D W Crabb; H J Edenberg; W F Bosron; T K Li
Journal: J Clin Invest Date: 1989-01 Impact factor: 14.808

4. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese.

Authors: S Higuchi; S Matsushita; T Muramatsu; M Murayama; M Hayashida
Journal: Alcohol Clin Exp Res Date: 1996-05 Impact factor: 3.455

5. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression.

Authors: S Fuke; S Suo; N Takahashi; H Koike; N Sasagawa; S Ishiura
Journal: Pharmacogenomics J Date: 2001 Impact factor: 3.550

Review 6. Genetic factors in alcohol metabolism and alcoholism.

Authors: W F Bosron; T Ehrig; T K Li
Journal: Semin Liver Dis Date: 1993-05 Impact factor: 6.115

7. Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population.

Authors: T Takeshita; K Morimoto; X Mao; T Hashimoto; J Furuyama
Journal: Hum Genet Date: 1994-09 Impact factor: 4.132

8. The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.

Authors: Jörn Lötsch; Carsten Skarke; Sabine Grösch; Jutta Darimont; Helmut Schmidt; Gerd Geisslinger
Journal: Pharmacogenetics Date: 2002-01

9. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.

Authors: C Bond; K S LaForge; M Tian; D Melia; S Zhang; L Borg; J Gong; J Schluger; J A Strong; S M Leal; J A Tischfield; M J Kreek; L Yu
Journal: Proc Natl Acad Sci U S A Date: 1998-08-04 Impact factor: 11.205

10. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.

Authors: W H Berrettini; T N Ferraro; R C Alexander; A M Buchberg; W H Vogel
Journal: Nat Genet Date: 1994-05 Impact factor: 38.330

42 in total

1. Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory.

Authors: Shirley Y Hill; Sarah Lichenstein; Shuhui Wang; Howard Carter; Michael McDermott
Journal: Adv J Mol Imaging Date: 2013-10-01

Genes associated with addiction: alcoholism, opiate, and cocaine addiction.

1. Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.

2. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.

3. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

4. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese.

5. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression.

Review 6. Genetic factors in alcohol metabolism and alcoholism.

7. Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population.

8. The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.

9. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.

10. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.

1. Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory.

Review 2. Stress, dysregulation of drug reward pathways, and the transition to drug dependence.

Review 3. Role of a functional human gene polymorphism in stress responsivity and addictions.

4. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.

Review 5. The neurobiology and genetics of impulse control disorders: relationships to drug addictions.

Review 6. Genetics of impulse control disorders in Parkinson's disease.

7. Parenting moderates a genetic vulnerability factor in longitudinal increases in youths' substance use.

Review 8. Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management.

Review 9. Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.

10. Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction.