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Literature DB >> 14994989

Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione.

Ivana Cacciatore¹, Antonio Di Stefano, Grazia Luisi, Francesco Pinnen, Piera Sozio.

Abstract

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the gamma-Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms.

Entities: Chemical

Mesh：

Substances：
Peptides
Glutathione

Year: 2004 PMID： 14994989 DOI： 10.1002/psc.501

Source DB: PubMed Journal: J Pept Sci ISSN： 1075-2617 Impact factor: 1.905

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Cited

2 in total

Review 1. Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems.

Authors: Ivana Cacciatore; Leonardo Baldassarre; Erika Fornasari; Adriano Mollica; Francesco Pinnen
Journal: Oxid Med Cell Longev Date: 2012-06-03 Impact factor: 6.543

2. Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.

Authors: Thimmalapura M Vishwanatha; Enrico Bergamaschi; Alexander Dömling
Journal: Org Lett Date: 2017-06-05 Impact factor: 6.005

2 in total