| Literature DB >> 14994192 |
In-Hye Park1, So-Young Jeon, Hee-Ju Lee, Sang-In Kim, Kyung-Sik Song.
Abstract
In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14994192 DOI： 10.1055/s-2004-815491
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352