OBJECTIVE: To determine whether depression is associated with cardiac autonomic alterations in elderly patients with recent acute coronary syndromes (ACSs). METHODS: Cross-sectional study on the association between a major depressive episode or isolated depressive symptoms (21-item Hamilton depression score) and heart rate variability abnormalities in 56 adults (31 women, 55%) 60 years of age and older with a recent (24-72 h) myocardial infarction (MI) or unstable angina (UA). RESULTS: Spectral and nonspectral parameters of respiratory sinus arrhythmia, indicative of parasympathetic activity on the heart, were decreased in patients with depression (high-frequency heart rate variability [log ms(2)] 2.12+/-0.4 vs. 2.52+/-0.5, P=.024; pNN50 [%] 1+/-2 vs. 9+/-15, P=.006; and rMSNN [ms] 16+/-6 vs. 28+/-22, P=.009). Also, high-frequency heart rate variability decreased with increasing depressive symptom severity. CONCLUSION: In a sample of older adults suffering from ACSs, depression was associated with impaired parasympathetic control of the heart.
OBJECTIVE: To determine whether depression is associated with cardiac autonomic alterations in elderly patients with recent acute coronary syndromes (ACSs). METHODS: Cross-sectional study on the association between a major depressive episode or isolated depressive symptoms (21-item Hamilton depression score) and heart rate variability abnormalities in 56 adults (31 women, 55%) 60 years of age and older with a recent (24-72 h) myocardial infarction (MI) or unstable angina (UA). RESULTS: Spectral and nonspectral parameters of respiratory sinus arrhythmia, indicative of parasympathetic activity on the heart, were decreased in patients with depression (high-frequency heart rate variability [log ms(2)] 2.12+/-0.4 vs. 2.52+/-0.5, P=.024; pNN50 [%] 1+/-2 vs. 9+/-15, P=.006; and rMSNN [ms] 16+/-6 vs. 28+/-22, P=.009). Also, high-frequency heart rate variability decreased with increasing depressive symptom severity. CONCLUSION: In a sample of older adults suffering from ACSs, depression was associated with impaired parasympathetic control of the heart.
Authors: Robert M Carney; Kenneth E Freedland; Phyllis K Stein; Brian C Steinmeyer; William S Harris; Eugene H Rubin; Ronald J Krone; Michael W Rich Journal: Psychosom Med Date: 2010-08-17 Impact factor: 4.312
Authors: Katherine A Sauder; Ann C Skulas-Ray; Tavis S Campbell; Jillian A Johnson; Penny M Kris-Etherton; Sheila G West Journal: Psychosom Med Date: 2013-04-16 Impact factor: 4.312
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Authors: Erica B Royster; Lisa M Trimble; George Cotsonis; Brian Schmotzer; Amita Manatunga; Natasha N Rushing; Giuseppe Pagnoni; S Freda Auyeung; Angelo R Brown; Joel Schoenbeck; Smitha Murthy; William M McDonald; Dominique L Musselman Journal: Cardiovasc Psychiatry Neurol Date: 2012-08-27