Robert Swift1. 1. Brown University, Providence VA Medical Center, Providence, RI 02908, USA. Robert_Swift@brown.edu
Abstract
BACKGROUND: Ethanol can be easily and accurately measured in body fluids or vapours by several chemical and enzymatic methods. However, the persistence of ethanol in the body is short lived and ethanol's metabolism and distribution within the body are extremely complex. AIM: This article discusses the complex pharmacokinetics of ethanol and how pharmacokinetics can affect measured ethanol concentrations when ethanol is sampled across different individuals or from different body fluids or vapors, such as whole blood, plasma, breath, urine, saliva, or transdermal ethanol. FINDINGS: Several physical methods for the quantification of ethanol concentrations are described, including gas chromatography, electrochemical detection, infrared detection and enzymatic methods, along with their advantages and limitations. Also discussed, is the utility of the measurement of several immediate metabolites of ethanol, including acetaldehyde. acetate, and fatty acid ethyl esters. CONCLUSIONS: The complex distribution and metabolism of ethanol and its metabolites can obscure the relationship between the ethanol concentration that is measured in body fluids or vapours and the amount of ethanol that is actually taken into the body.
BACKGROUND:Ethanol can be easily and accurately measured in body fluids or vapours by several chemical and enzymatic methods. However, the persistence of ethanol in the body is short lived and ethanol's metabolism and distribution within the body are extremely complex. AIM: This article discusses the complex pharmacokinetics of ethanol and how pharmacokinetics can affect measured ethanol concentrations when ethanol is sampled across different individuals or from different body fluids or vapors, such as whole blood, plasma, breath, urine, saliva, or transdermal ethanol. FINDINGS: Several physical methods for the quantification of ethanol concentrations are described, including gas chromatography, electrochemical detection, infrared detection and enzymatic methods, along with their advantages and limitations. Also discussed, is the utility of the measurement of several immediate metabolites of ethanol, including acetaldehyde. acetate, and fatty acid ethyl esters. CONCLUSIONS: The complex distribution and metabolism of ethanol and its metabolites can obscure the relationship between the ethanol concentration that is measured in body fluids or vapours and the amount of ethanol that is actually taken into the body.
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