| Literature DB >> 14980676 |
Roland W Bürli1, Dustin McMinn, Jacob A Kaizerman, Wenhao Hu, Yigong Ge, Quinn Pack, Vernon Jiang, Matthew Gross, Martin Garcia, Richard Tanaka, Heinz E Moser.
Abstract
Novel DNA minor-groove binding ligands with a promising antibacterial profile are described. Apart from excellent in vitro potency against multiple Gram-positive bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), and penicillin-intermediate Streptococcus pneumoniae (PISP), a small subset of compounds was active against Gram-negative bacteria such as Escherichia coli (E. coli).Entities:
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Year: 2004 PMID： 14980676 DOI： 10.1016/j.bmcl.2003.12.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823