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Literature DB >> 27840672

Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution.

C H Castaneda¹, M J Scuderi¹, T G Edwards¹, G D Harris¹, C M Dupureur¹, K J Koeller¹, C Fisher², J K Bashkin³.

Abstract

We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC90 values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.

Entities: CellLine Chemical Disease Gene Species

Year: 2016 PMID： 27840672 PMCID： PMC5101016 DOI： 10.1039/C6MD00371K

Source DB: PubMed Journal: Medchemcomm ISSN： 2040-2503 Impact factor: 3.597

46 in total

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5. Interactions of two large antiviral polyamides with the long control region of HPV16.

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Review 6. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus.

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7. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women.

Authors: Elmar A Joura; Anna R Giuliano; Ole-Erik Iversen; Celine Bouchard; Constance Mao; Jesper Mehlsen; Edson D Moreira; Yuen Ngan; Lone Kjeld Petersen; Eduardo Lazcano-Ponce; Punnee Pitisuttithum; Jaime Alberto Restrepo; Gavin Stuart; Linn Woelber; Yuh Cheng Yang; Jack Cuzick; Suzanne M Garland; Warner Huh; Susanne K Kjaer; Oliver M Bautista; Ivan S F Chan; Joshua Chen; Richard Gesser; Erin Moeller; Michael Ritter; Scott Vuocolo; Alain Luxembourg
Journal: N Engl J Med Date: 2015-02-19 Impact factor: 91.245

Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution.

1. Footprinting with an automated capillary DNA sequencer.

2. DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives.

3. What is the antiviral potential of pyrrole-imidazole polyamides?

4. ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.

5. Interactions of two large antiviral polyamides with the long control region of HPV16.

Review 6. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus.

7. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women.

8. Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

9. Effects of the A.T/T.A degeneracy of pyrrole--imidazole polyamide recognition in the minor groove of DNA.

10. Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.

1. A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid.

Review 2. Subversion of Host Innate Immunity by Human Papillomavirus Oncoproteins.