| Literature DB >> 14980634 |
P Rajender Kumar1, S Raju, P Satish Goud, M Sailaja, M R Sarma, G Om Reddy, M Prem Kumar, V V R M Krishna Reddy, T Suresh, Pragathi Hegde.
Abstract
A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups.Entities:
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Year: 2004 PMID： 14980634 DOI： 10.1016/j.bmc.2003.11.003
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641