PURPOSE AND EXPERIMENTAL DESIGN: To test whether plasminogen activator inhibitor-1 (PAI-1) can serve as a candidate marker for the malignancy of esophageal squamous cell carcinoma (SCC), we performed a quantitative reverse transcription-PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in esophageal SCC. RESULTS: Significant increases in PAI-1 scores were observed in metastasis-positive esophageal SCCs (3.08 +/- 0.80) compared with metastasis-negative ones (-0.31 +/- 0.62; P = 0.0042). PAI-1 expression scores significantly increased with tumor stage (P = 0.05, ANOVA). CONCLUSIONS: These results suggested that PAI-1 might serve as a new parameter for prediction of prognosis in esophageal SCC.
PURPOSE AND EXPERIMENTAL DESIGN: To test whether plasminogen activator inhibitor-1 (PAI-1) can serve as a candidate marker for the malignancy of esophageal squamous cell carcinoma (SCC), we performed a quantitative reverse transcription-PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in esophageal SCC. RESULTS: Significant increases in PAI-1 scores were observed in metastasis-positive esophageal SCCs (3.08 +/- 0.80) compared with metastasis-negative ones (-0.31 +/- 0.62; P = 0.0042). PAI-1 expression scores significantly increased with tumor stage (P = 0.05, ANOVA). CONCLUSIONS: These results suggested that PAI-1 might serve as a new parameter for prediction of prognosis in esophageal SCC.
Authors: Aysegul Bayramoglu; Hasan Veysi Gunes; Muzaffer Metintas; Irfan Degirmenci; Halil Ibrahim Guler; Cengiz Ustuner; Ahmet Musmul Journal: Genet Test Mol Biomarkers Date: 2014-06-23
Authors: Philippe Leissner; Thibault Verjat; Thomas Bachelot; Malick Paye; Alexander Krause; Alain Puisieux; Bruno Mougin Journal: BMC Cancer Date: 2006-08-31 Impact factor: 4.430
Authors: Elizabeth Fabre-Guillevin; Michel Malo; Amandine Cartier-Michaud; Hector Peinado; Gema Moreno-Bueno; Benoît Vallée; Daniel A Lawrence; José Palacios; Amparo Cano; Georgia Barlovatz-Meimon; Cécile Charrière-Bertrand Journal: Breast Cancer Res Date: 2008-12-03 Impact factor: 6.466