OBJECTIVE: To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41). METHODS: Subjects used each medication on arising (1/2 day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences. RESULTS: Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs. CONCLUSION: Subjects had varied reactions to NRTs that may affect initiation of cessation.
RCT Entities:
OBJECTIVE: To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41). METHODS: Subjects used each medication on arising (1/2 day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences. RESULTS: Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs. CONCLUSION: Subjects had varied reactions to NRTs that may affect initiation of cessation.
Authors: Nina G Schneider; Scott Terrace; Margaret A Koury; Shilpan Patel; Behram Vaghaiwalla; Regina Pendergrass; Richard E Olmstead; Chris Cortner Journal: Psychopharmacology (Berl) Date: 2005-10-19 Impact factor: 4.530
Authors: Nina G Schneider; Margaret A Koury; Chris Cortner; Richard E Olmstead; Neil Hartman; Leonard Kleinman; Andrew Kim; Craig Chaya; David Leaf Journal: Psychopharmacology (Berl) Date: 2006-08-01 Impact factor: 4.530
Authors: Jeffrey S Stein; A George Wilson; Mikhail N Koffarnus; Michael C Judd; Warren K Bickel Journal: Psychopharmacology (Berl) Date: 2016-10-11 Impact factor: 4.530
Authors: Katie L Nugent; Amber Million-Mrkva; Joshua Backman; Sarah H Stephens; Robert M Reed; Peter Kochunov; Toni I Pollin; Alan R Shuldiner; Braxton D Mitchell; L Elliot Hong Journal: Nicotine Tob Res Date: 2014-02-28 Impact factor: 4.244
Authors: Cheryl Oncken; Ellen A Dornelas; Chia-Ling Kuo; Heather Z Sankey; Henry R Kranzler; Erin L Mead; Ms Sheila D Thurlow Journal: Am J Obstet Gynecol MFM Date: 2019-03-27