Literature DB >> 14973583

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations.

Max J Cryle1, Julia M U Stuthe, Paul R Ortiz de Montellano, James J De Voss.   

Abstract

Novel cyclopropyl containing fatty acids are good substrates for P450(BM3) catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 10(10) s(-1)) and the absence of any cationic intermediate.

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Year:  2004        PMID: 14973583     DOI: 10.1039/b315911f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Rearrangement reactions catalyzed by cytochrome P450s.

Authors:  Paul R Ortiz de Montellano; Sidney D Nelson
Journal:  Arch Biochem Biophys       Date:  2010-10-29       Impact factor: 4.013

2.  Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.

Authors:  Yongying Jiang; Xiang He; Paul R Ortiz de Montellano
Journal:  Biochemistry       Date:  2006-01-17       Impact factor: 3.162

  2 in total

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