| Literature DB >> 14973298 |
Abstract
Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.Entities:
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Year: 2004 PMID: 14973298 DOI: 10.1242/dev.01074
Source DB: PubMed Journal: Development ISSN: 0950-1991 Impact factor: 6.868