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Literature DB >> 19233264

Pancreatic cancer stem cells: fact or fiction?

Abstract

The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19233264 PMCID： PMC2670354 DOI： 10.1016/j.bbadis.2009.02.007

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

101 in total

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Journal: Cancer Res Date: 1961-09 Impact factor: 12.701

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Journal: Cancer Res Date: 1960-09 Impact factor: 12.701

4. Some characteristics of transplantable rat hepatoma No. 5123 induced by ingestion of N-(2-fluorenyl) phthalamic acid.

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Journal: Cancer Res Date: 1960-09 Impact factor: 12.701

5. Transplantable animal cancer, the primary standard.

Authors: V R POTTER
Journal: Cancer Res Date: 1961-11 Impact factor: 12.701

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Authors: G KLEIN; E KLEIN
Journal: Cancer Res Date: 1951-06 Impact factor: 12.701

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Authors: G KLEIN
Journal: Cancer Date: 1950-11 Impact factor: 6.860

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Authors: M A Lea; H P Morris; G Weber
Journal: Cancer Res Date: 1966-03 Impact factor: 12.701

20 in total

1. Increased expression of DNA repair genes in invasive human pancreatic cancer cells.

Authors: Lesley A Mathews; Stephanie M Cabarcas; Elaine M Hurt; Xiaohu Zhang; Elizabeth M Jaffee; William L Farrar
Journal: Pancreas Date: 2011-07 Impact factor: 3.327

2. Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.

Authors: Hanno Niess; Peter Camaj; Andrea Renner; Ivan Ischenko; Yue Zhao; Stefan Krebs; Josef Mysliwietz; Carsten Jäckel; Peter J Nelson; Helmut Blum; Karl-Walter Jauch; Joachim W Ellwart; Christiane J Bruns
Journal: Target Oncol Date: 2014-06-22 Impact factor: 4.493

10. Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells.

Authors: Leilei Tang; Saskia M Bergevoet; Christian Gilissen; Theo de Witte; Joop H Jansen; Bert A van der Reijden; Reinier A P Raymakers
Journal: BMC Pharmacol Date: 2010-09-13

Pancreatic cancer stem cells: fact or fiction?

1. Correlation of chromosomal and physiologic changes in tumors.

2. The chromosomes in ontogeny and oncogeny.

3. The comparative enzymology and cell origin of rat hepatomas. I. Deoxycytidylate deaminase and thymine degradation.

4. Some characteristics of transplantable rat hepatoma No. 5123 induced by ingestion of N-(2-fluorenyl) phthalamic acid.

5. Transplantable animal cancer, the primary standard.

6. The transformation of a solid transplantable mouse carcinoma into an "ascites tumor".

7. Use of the Ehrlich ascites tumor of mice for quantitative studies on the growth and biochemistry of neoplastic cells.

8. Some aspects of the development, biology and biochemistry of rat hepatomas of different growth rate.

Review 9. Studies on the development, biochemistry, and biology of experimental hepatomas.

10. Comparative biochemistry of hepatomas. VI. Thymidine incorporation into DNA as a measure of hepatoma growth rate.

1. Increased expression of DNA repair genes in invasive human pancreatic cancer cells.

2. Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.

Review 3. Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.

4. SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.

5. Isolation of Lipid Raft Proteins from CD133+ Cancer Stem Cells.

Review 6. Advances in biomarker research for pancreatic cancer.

Review 7. Pancreatic cancer stem cells: features and detection methods.

8. Electron microscopic analysis of different cell types in human pancreatic cancer spheres.

9. Tumor initiating cells in pancreatic cancer: A critical view.

10. Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells.