OBJECTIVES: To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population. METHOD: NT-proBNP and cystatin C were analyzed in 407 and 408 healthy individuals, median age: 65 (range 40-76). RESULTS: Increasing age, female gender and CRP were independently associated to higher NT-proBNP levels. Age, body mass index, and CRP level were independently associated to the cystatin C level. In women and men, < or =65 years, the 97.5th percentile value for NT-proBNP was 268 ng/l and 184 ng/l, in those older, 391 ng/l and 269 ng/l. For those < or =65 years the 97.5th percentile value for cystatin C was 1.12 mg/l, and for those older 1.21 mg/l. CONCLUSION: In a healthy elderly population, NT-proBNP is influenced by age and gender, whereas cystatin C is influenced by age but not by gender. Both markers seem to be associated to the CRP level.
OBJECTIVES: To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population. METHOD: NT-proBNP and cystatin C were analyzed in 407 and 408 healthy individuals, median age: 65 (range 40-76). RESULTS: Increasing age, female gender and CRP were independently associated to higher NT-proBNP levels. Age, body mass index, and CRP level were independently associated to the cystatin C level. In women and men, < or =65 years, the 97.5th percentile value for NT-proBNP was 268 ng/l and 184 ng/l, in those older, 391 ng/l and 269 ng/l. For those < or =65 years the 97.5th percentile value for cystatin C was 1.12 mg/l, and for those older 1.21 mg/l. CONCLUSION: In a healthy elderly population, NT-proBNP is influenced by age and gender, whereas cystatin C is influenced by age but not by gender. Both markers seem to be associated to the CRP level.
Authors: Martin Andreas; Harald Zeisler; Ammon Handisurya; Maximilian B Franz; Michael Gottsauner-Wolf; Michael Wolzt; Alexandra Kautzky-Willer Journal: Cardiovasc Diabetol Date: 2011-04-13 Impact factor: 9.951
Authors: Spyros Darmanis; Rachel Yuan Nong; Johan Vänelid; Agneta Siegbahn; Olle Ericsson; Simon Fredriksson; Christofer Bäcklin; Marta Gut; Simon Heath; Ivo Glynne Gut; Lars Wallentin; Mats G Gustafsson; Masood Kamali-Moghaddam; Ulf Landegren Journal: PLoS One Date: 2011-09-29 Impact factor: 3.240
Authors: Ziad Hijazi; Bertil Lindahl; Jonas Oldgren; Ulrika Andersson; Johan Lindbäck; Christopher B Granger; John H Alexander; Bernard J Gersh; Michael Hanna; Veli-Pekka Harjola; Elaine M Hylek; Renato D Lopes; Agneta Siegbahn; Lars Wallentin Journal: J Am Heart Assoc Date: 2017-06-23 Impact factor: 5.501