BACKGROUND: Primary progressive aphasia (PPA) leads to a gradual and relatively isolated dissolution of language function. The factors that determine the selectivity of the disease process remain unknown. We had speculated that PPA may occasionally arise as a tardive manifestation of genetic or acquired vulnerabilities involving the language network of the brain. OBJECTIVE: To explore predisposing factors for PPA. RESULTS: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia. CONCLUSION: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.
BACKGROUND:Primary progressive aphasia (PPA) leads to a gradual and relatively isolated dissolution of language function. The factors that determine the selectivity of the disease process remain unknown. We had speculated that PPA may occasionally arise as a tardive manifestation of genetic or acquired vulnerabilities involving the language network of the brain. OBJECTIVE: To explore predisposing factors for PPA. RESULTS: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia. CONCLUSION: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.
Authors: Zachary A Miller; Leighton B Hinkley; Alex Herman; Susanne Honma; Anne Findlay; Nikolas Block; Robin Ketelle; Gil Rabinovici; Howard Rosen; Srikantan S Nagarajan; Bruce L Miller; Maria Luisa Gorno-Tempini Journal: Neurology Date: 2014-12-03 Impact factor: 9.910
Authors: Zachary A Miller; Maria Luisa Mandelli; Katherine P Rankin; Maya L Henry; Miranda C Babiak; Darvis T Frazier; Iryna V Lobach; Brianne M Bettcher; Teresa Q Wu; Gil D Rabinovici; Neill R Graff-Radford; Bruce L Miller; Maria Luisa Gorno-Tempini Journal: Brain Date: 2013-09-20 Impact factor: 13.501
Authors: Zachary A Miller; Lynne Rosenberg; Miguel A Santos-Santos; Melanie Stephens; Isabel E Allen; H Isabel Hubbard; Averill Cantwell; Maria Luisa Mandelli; Lea T Grinberg; William W Seeley; Bruce L Miller; Gil D Rabinovici; Maria Luisa Gorno-Tempini Journal: JAMA Neurol Date: 2018-06-01 Impact factor: 18.302