BACKGROUND: Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). OBJECTIVE: To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. DESIGN, SETTING, AND PATIENTS: Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information. MAIN OUTCOME MEASURE: Prevalence of LDs among probands and their first-degree relatives. RESULTS: The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia. CONCLUSION: These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome.
BACKGROUND: Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). OBJECTIVE: To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. DESIGN, SETTING, AND PATIENTS: Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information. MAIN OUTCOME MEASURE: Prevalence of LDs among probands and their first-degree relatives. RESULTS: The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia. CONCLUSION: These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome.
Authors: J B Chawluk; M M Mesulam; H Hurtig; M Kushner; S Weintraub; A Saykin; N Rubin; A Alavi; M Reivich Journal: Ann Neurol Date: 1986-01 Impact factor: 10.422
Authors: Jessica A Collins; Victor Montal; Daisy Hochberg; Megan Quimby; Maria Luisa Mandelli; Nikos Makris; William W Seeley; Maria Luisa Gorno-Tempini; Bradford C Dickerson Journal: Brain Date: 2016-12-31 Impact factor: 13.501
Authors: Zachary A Miller; Maria Luisa Mandelli; Katherine P Rankin; Maya L Henry; Miranda C Babiak; Darvis T Frazier; Iryna V Lobach; Brianne M Bettcher; Teresa Q Wu; Gil D Rabinovici; Neill R Graff-Radford; Bruce L Miller; Maria Luisa Gorno-Tempini Journal: Brain Date: 2013-09-20 Impact factor: 13.501
Authors: Ana S Costa; Regina Jokel; Alberto Villarejo; Sara Llamas-Velasco; Kimiko Domoto-Reilley; Jennifer Wojtala; Kathrin Reetz; Álvaro Machado Journal: Alzheimer Dis Assoc Disord Date: 2019 Jan-Mar Impact factor: 2.703
Authors: Manja Lehmann; Pia M Ghosh; Cindee Madison; Robert Laforce; Chiara Corbetta-Rastelli; Michael W Weiner; Michael D Greicius; William W Seeley; Maria L Gorno-Tempini; Howard J Rosen; Bruce L Miller; William J Jagust; Gil D Rabinovici Journal: Brain Date: 2013-01-28 Impact factor: 13.501