T M E Davis1, P Fortun2, J Mulder2, W A Davis2, D G Bruce2. 1. University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia. tdavis@cyllene.uwa.edu.au. 2. University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia.
Abstract
AIMS/HYPOTHESIS: Our study investigated the prognosis of Type 2 diabetic patients with silent myocardial infarction in a community-based cohort. METHODS: We analysed data from 1269 patients with Type 2 diabetes mellitus from a community-based observational study of diabetes care, control and complications. Silent myocardial infarction was defined as Q waves (Minnesota codes 1.1, 1.2) on a baseline electrocardiogram in the absence of a history or symptoms of CHD. RESULTS: Silent myocardial infarction was present in 3.9% of patients, or 44% of all Q-wave myocardial infarctions. The patients were subdivided into those with (i). no clinical or Q-wave evidence of myocardial infarction (Group 1), (ii). silent myocardial infarction (Group 2), (iii). self-reported CHD but no Q waves (Group 3), and (iv) self-reported CHD and Q waves (Group 4). Compared to Groups 3 and 4, Group 2 patients were more likely to be women, less likely to have smoked, and had higher serum HDL-cholesterol concentrations and higher blood pressure. Over an average of seven years, and after adjusting for other independent predictors of death, all-cause and CHD mortality were similar in Groups 1 and 2 and greater (twofold for all-cause and fourfold for CHD mortality) in Groups 3 and 4. CONCLUSIONS/ INTERPRETATION: Silent myocardial infarction is common in Type 2 diabetes and has a prognosis similar to that in patients without a history of CHD or Q waves.
AIMS/HYPOTHESIS: Our study investigated the prognosis of Type 2 diabeticpatients with silent myocardial infarction in a community-based cohort. METHODS: We analysed data from 1269 patients with Type 2 diabetes mellitus from a community-based observational study of diabetes care, control and complications. Silent myocardial infarction was defined as Q waves (Minnesota codes 1.1, 1.2) on a baseline electrocardiogram in the absence of a history or symptoms of CHD. RESULTS:Silent myocardial infarction was present in 3.9% of patients, or 44% of all Q-wave myocardial infarctions. The patients were subdivided into those with (i). no clinical or Q-wave evidence of myocardial infarction (Group 1), (ii). silent myocardial infarction (Group 2), (iii). self-reported CHD but no Q waves (Group 3), and (iv) self-reported CHD and Q waves (Group 4). Compared to Groups 3 and 4, Group 2 patients were more likely to be women, less likely to have smoked, and had higher serum HDL-cholesterol concentrations and higher blood pressure. Over an average of seven years, and after adjusting for other independent predictors of death, all-cause and CHD mortality were similar in Groups 1 and 2 and greater (twofold for all-cause and fourfold for CHD mortality) in Groups 3 and 4. CONCLUSIONS/ INTERPRETATION:Silent myocardial infarction is common in Type 2 diabetes and has a prognosis similar to that in patients without a history of CHD or Q waves.
Authors: J Nadelmann; W H Frishman; W L Ooi; D Tepper; S Greenberg; H Guzik; E J Lazar; M Heiman; M Aronson Journal: Am J Cardiol Date: 1990-09-01 Impact factor: 2.778
Authors: D G Bruce; W A Davis; G P Casey; S E Starkstein; R M Clarnette; J K Foster; O P Almeida; T M E Davis Journal: Diabetologia Date: 2007-12-05 Impact factor: 10.122
Authors: D G Bruce; G Casey; W A Davis; S E Starkstein; R C Clarnette; J K Foster; F J Ives; O P Almeida; T M E Davis Journal: Diabetologia Date: 2006-10-13 Impact factor: 10.122
Authors: Zhu-Ming Zhang; Pentti M Rautaharju; Ronald J Prineas; Carlos J Rodriguez; Laura Loehr; Wayne D Rosamond; Dalane Kitzman; David Couper; Elsayed Z Soliman Journal: Circulation Date: 2016-05-16 Impact factor: 29.690
Authors: Richard Brandon Stacey; Janice Zgibor; Paul E Leaverton; Douglas D Schocken; Jennifer A Peregoy; Mary F Lyles; Alain G Bertoni; Gregory L Burke Journal: J Am Geriatr Soc Date: 2018-10-09 Impact factor: 5.562
Authors: Emma J Hamilton; Natalie Martin; Ashley Makepeace; Brett A Sillars; Wendy A Davis; Timothy M E Davis Journal: PLoS One Date: 2013-03-25 Impact factor: 3.240
Authors: Emily B Levitan; Christopher Gamboa; Monika M Safford; Dana V Rizk; Todd M Brown; Elsayed Z Soliman; Paul Muntner Journal: Vasc Health Risk Manag Date: 2013-02-05