Literature DB >> 14962597

The condition for pseudo-first-order kinetics in enzymatic reactions is independent of the initial enzyme concentration.

S Schnell1, C Mendoza.   

Abstract

The linearization of the Michaelis-Menten reaction by pseudo-first-order kinetics is revised. A phase-plane analysis allows the derivation of a new condition for its validity that is directly linked to the reaction efficiency, and contrary to widely established knowledge, is independent of the initial enzyme concentration.

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Year:  2004        PMID： 14962597     DOI： 10.1016/j.bpc.2003.09.003

Source DB:  PubMed          Journal:  Biophys Chem        ISSN： 0301-4622            Impact factor:   2.352


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