Literature DB >> 14961345

Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis.

K Suetsuna1, J R Chen.   

Abstract

The peptidic fractions that inhibited angiotensin I-converting enzyme (ACE) were separated from the peptic digests of 2 microalgae, Chlorella vulgaris and Spirulina platensis, by ion exchange chromatography and gel filtration. Oral administration of peptidic fractions into spontaneously hypertensive rats at 200 mg/kg of body weight resulted in marked antihypertensive effects. Further separation of the peptidic fractions by ODS high-performance liquid chromatography furnished the following active peptides: Ile-Val-Val-Glu (inhibitory against ACE with an IC(50) of 315.3 microM), Ala-Phe-Leu (63.8 microM), Phe-Ala-Leu (26.3 microM), Ala-Glu-Leu (57.1 microM), and Val-Val-Pro-Pro-Ala (79.5 microM) from C. vulgaris; Ile-Ala-Glu (34.7 microM), Phe-Ala-Leu, Ala-Glu-Leu, Ile-Ala-Pro-Gly (11.4 microM), and Val-Ala-Phe (35.8 microM) from S. platensis.

Entities:  

Year:  2001        PMID： 14961345     DOI： 10.1007/s10126-001-0012-7

Source DB:  PubMed          Journal:  Mar Biotechnol (NY)        ISSN： 1436-2228            Impact factor:   3.619


  23 in total

1.  Investigation of in vitro digestibility of dietary microalga Chlorella vulgaris and cyanobacterium Spirulina platensis as a nutritional supplement.

Authors:  Ayse Kose; Mehmet O Ozen; Murat Elibol; Suphi S Oncel
Journal:  3 Biotech       Date:  2017-06-29       Impact factor: 2.406

2.  Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats.

Authors:  Su-Ching Yang; Hsin-Yi Yang; Yi-Ching Yang; Hsiang-Chi Peng; Pei-Yin Ho
Journal:  Eur J Nutr       Date:  2012-05-03       Impact factor: 5.614

3.  Identification and Inhibitory Mechanism of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bovine Hemoglobin.

Authors:  Ying Wang; Yiqun Jiang; Yongguang Yin; Jiyun Liu; Long Ding; Jingbo Liu; Ting Zhang
Journal:  Protein J       Date:  2017-06       Impact factor: 2.371

4.  Supercritical CO2 extraction of functional compounds from Spirulina and their biological activity.

Authors:  Mallikarjun Gouda K G; Udaya Sankar K; Sarada R; Ravishankar G A
Journal:  J Food Sci Technol       Date:  2014-06-06       Impact factor: 2.701

5.  An Investigation of Pepsin Hydrolysate of Short Antibacterial Peptides Derived from Limnospira Sp.

Authors:  Sathya R; MubarakAli D; Mehboob Nousheen M G; Vasimalai N; Thajuddin N; Jung-Wan Kim
Journal:  Appl Biochem Biotechnol       Date:  2022-07-06       Impact factor: 3.094

Review 6.  Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry.

Authors:  Isuru Wijesekara; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2010-03-31       Impact factor: 5.118

Review 7.  Potential anti-HIV agents from marine resources: an overview.

Authors:  Thanh-Sang Vo; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2010-11-29       Impact factor: 5.118

Review 8.  Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer.

Authors:  Elena Talero; Sofía García-Mauriño; Javier Ávila-Román; Azahara Rodríguez-Luna; Antonio Alcaide; Virginia Motilva
Journal:  Mar Drugs       Date:  2015-09-30       Impact factor: 5.118

9.  A heptameric peptide purified from Spirulina sp. gastrointestinal hydrolysate inhibits angiotensin I-converting enzyme- and angiotensin II-induced vascular dysfunction in human endothelial cells.

Authors:  Seong-Yeong Heo; Seok-Chun Ko; Chang Su Kim; Gun-Woo Oh; Bomi Ryu; Zhong-Ji Qian; Geunhyung Kim; Won Sun Park; Il-Whan Choi; Thi Tuong Vy Phan; Soo-Jin Heo; Do-Hyung Kang; Myunggi Yi; Won-Kyo Jung
Journal:  Int J Mol Med       Date:  2017-04-04       Impact factor: 4.101

Review 10.  Algal Proteins: Extraction, Application, and Challenges Concerning Production.

Authors:  Stephen Bleakley; Maria Hayes
Journal:  Foods       Date:  2017-04-26
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