Literature DB >> 149514

Effect of N'-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats.

R Jerauld, F J Silverblatt.   

Abstract

N'-methylnicotinamide, a substrate of the organic base transport system, reduced renal accumulation of [(14)C]gentamicin in rats by 15% and increased clearance by 25%, suggesting that gentamicin is not secreted by this mechanism.

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Year:  1978        PMID： 149514      PMCID： PMC352352          DOI： 10.1128/AAC.13.5.893

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Effect of cephalothin on renal cortical concentrations of gentamicin in rats.

Authors:  P Dellinger; T Murphy; M Barza; V Pinn; L Weinstein
Journal:  Antimicrob Agents Chemother       Date:  1976-04       Impact factor: 5.191

2.  Experimental aminoglycoside nephrotoxicity.

Authors:  F C Luft; V Patel; M N Yum; B Patel; S A Kleit
Journal:  J Lab Clin Med       Date:  1975-08

3.  Renal excretion of N'1-methylnicotinamide in the rat.

Authors:  C R Ross; F Diezi-Chomety; F Roch-Ramel
Journal:  Am J Physiol       Date:  1975-06

4.  Renal extraction of gentamicin in anesthetized dogs.

Authors:  P J Chiu; A Brown; G Miller; J F Long
Journal:  Antimicrob Agents Chemother       Date:  1976-08       Impact factor: 5.191

5.  Concentrations of gentamicin and amikacin in human kidneys.

Authors:  C Q Edwards; C R Smith; K L Baughman; J F Rogers; P S Lietman
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

Review 6.  Editorial: Intrarenal antibiotic distribution in health and disease.

Authors:  A Whelton; W G Walker
Journal:  Kidney Int       Date:  1974-09       Impact factor: 10.612

7.  Regulation of plasma choline by the renal tubule: bidirectional transport of choline.

Authors:  M Acara; B Rennick
Journal:  Am J Physiol       Date:  1973-11
  7 in total
  1 in total

Review 1.  Clinical pharmacokinetics of aminoglycoside antibiotics.

Authors:  J C Pechere; R Dugal
Journal:  Clin Pharmacokinet       Date:  1979 May-Jun       Impact factor: 6.447
  1 in total

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