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Literature DB >> 1267436

Effect of cephalothin on renal cortical concentrations of gentamicin in rats.

P Dellinger, T Murphy, M Barza, V Pinn, L Weinstein.

Abstract

Renal cortical concentrations of gentamicin were significantly lower in rats given this aminoglycoside and cephalothin simultaneously than in animals given gentamicin alone. This effect may be responsible, in part, for the reduction in nephrotoxicity reported previously in animals given the combination of drugs.

Entities: Chemical Disease Species

Mesh：

Substances：
Gentamicins
Cephalothin

Year: 1976 PMID： 1267436 PMCID： PMC429582 DOI： 10.1128/AAC.9.4.587

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

Review 1. Editorial: Intrarenal antibiotic distribution in health and disease.

Authors: A Whelton; W G Walker
Journal: Kidney Int Date: 1974-09 Impact factor: 10.612

2. Renal parenchymal accumulation of aminoglycoside antibiotics in rats.

Authors: F C Luft; S A Kleit
Journal: J Infect Dis Date: 1974-12 Impact factor: 5.226

3. Nephrotoxicity of gentamicin.

Authors: J C Kosek; R I Mazze; M J Cousins
Journal: Lab Invest Date: 1974-01 Impact factor: 5.662

4. Protective effect of cephalothin against gentamincin-induced nephrotoxicity in rats.

Authors: P Dellinger; T Murphy; V Pinn; M Barza; L Weinstein
Journal: Antimicrob Agents Chemother Date: 1976-01 Impact factor: 5.191

5. Predictability of blood levels of gentamicin in man.

Authors: M Barza; R B Brown; D Shen; M Gibaldi; L Weinstein
Journal: J Infect Dis Date: 1975-08 Impact factor: 5.226

6. Gentamicin nephrotoxicity: failure of three cephalosporins to potentiate injury in rats.

Authors: W O Harrison; F J Silverblatt; M Turck
Journal: Antimicrob Agents Chemother Date: 1975-08 Impact factor: 5.191

6 in total

10 in total

1. Effect of N'-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats.

Authors: R Jerauld; F J Silverblatt
Journal: Antimicrob Agents Chemother Date: 1978-05 Impact factor: 5.191

2. Protection from gentamicin nephrotoxicity by cephalothin and carbenicillin.

Authors: R Bloch; F C Luft; L I Rankin; R S Sloan; M N Yum; D R Maxwell
Journal: Antimicrob Agents Chemother Date: 1979-01 Impact factor: 5.191

3. Effect of timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity.

Authors: K Capel-Edwards; R M Atkinson; J M Wheeldon; D A Pratt; G G Patterson; I W Harman; R D Foord
Journal: Infection Date: 1980 Impact factor: 3.553

Review 4. Side effects of cephalosporins.

Authors: S R Norrby
Journal: Drugs Date: 1987 Impact factor: 9.546

Effect of cephalothin on renal cortical concentrations of gentamicin in rats.

Review 1. Editorial: Intrarenal antibiotic distribution in health and disease.

2. Renal parenchymal accumulation of aminoglycoside antibiotics in rats.

3. Nephrotoxicity of gentamicin.

4. Protective effect of cephalothin against gentamincin-induced nephrotoxicity in rats.

5. Predictability of blood levels of gentamicin in man.

6. Gentamicin nephrotoxicity: failure of three cephalosporins to potentiate injury in rats.

1. Effect of N'-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats.

2. Protection from gentamicin nephrotoxicity by cephalothin and carbenicillin.

3. Effect of timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity.

Review 4. Side effects of cephalosporins.

5. Effect of cefamandole nafate on the toxicity of tobramycin.

6. Comparison of the nephrotoxicity of netilmicin and gentamicin in rats.

7. Comparative nephrotoxicities of netilmicin and gentamicin in rats.

8. Tobramycin nephrotoxicity: failure of cefotaxime to potentiate renal toxicity.

Review 9. [Tobramycin concentrations in human renal tissue (author's transl)].

10. Nephrotoxicity of netilmicin in combination with non-aminoglycoside antibiotics.