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Literature DB >> 1492370

Antigenic variation in African trypanosomes.

L H Van der Ploeg¹, K Gottesdiener, M G Lee.

Abstract

African trypanosomes evade the humoral immune response by periodically changing the antigenic identity of their variant cell-surface glycoprotein (VSG) coat. Antigenic variation relies on DNA rearrangement events that can translocate a silent VSG gene to a telomerically located VSG gene expression site. Antigenic switches can also be brought about by the differential transcriptional control of the expression sites, only one of which is transcribed at any time.

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Year: 1992 PMID： 1492370 DOI： 10.1016/0168-9525(92)90330-7

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

23 in total

1. A double-strand break in a chromosomal LINE element can be repaired by gene conversion with various endogenous LINE elements in mouse cells.

Authors: A Tremblay; M Jasin; P Chartrand
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

2. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

Authors: Jill A Inverso; Timothy S Uphoff; Scott C Johnson; Donna M Paulnock; John M Mansfield
Journal: DNA Cell Biol Date: 2010-05 Impact factor: 3.311

3. T-cell responses to the trypanosome variant surface glycoprotein are not limited to hypervariable subregions.

Authors: Taylor R Dagenais; Karen P Demick; James D Bangs; Katrina T Forest; Donna M Paulnock; John M Mansfield
Journal: Infect Immun Date: 2008-10-20 Impact factor: 3.441

4. Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences.

Authors: R McCulloch; G Rudenko; P Borst
Journal: Mol Cell Biol Date: 1997-02 Impact factor: 4.272

5. Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi sl.

Authors: F T Liang; J M Nowling; M T Philipp
Journal: J Bacteriol Date: 2000-06 Impact factor: 3.490

6. Human immunodeficiency virus-infected patients with prior Pneumocystis pneumonia exhibit increased serologic reactivity to several major surface glycoprotein clones.

Authors: K R Daly; J V Koch; N J Shire; L Levin; P D Walzer
Journal: Clin Vaccine Immunol Date: 2006-10

Antigenic variation in African trypanosomes.

1. A double-strand break in a chromosomal LINE element can be repaired by gene conversion with various endogenous LINE elements in mouse cells.

2. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

3. T-cell responses to the trypanosome variant surface glycoprotein are not limited to hypervariable subregions.

4. Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences.

5. Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi sl.

6. Human immunodeficiency virus-infected patients with prior Pneumocystis pneumonia exhibit increased serologic reactivity to several major surface glycoprotein clones.

7. Analysis of Borrelia burgdorferi vlsE gene expression and recombination in the tick vector.

Review 8. Pneumocystis carinii: what is it, exactly?

Review 9. Protein trafficking in kinetoplastid protozoa.

10. PARP promoter-mediated activation of a VSG expression site promoter in insect form Trypanosoma brucei.