Literature DB >> 14888823

The effect of adrenocorticotropic hormone on inflammation due to tuberculin hypersensitivity and turpentine and on circulating antibody levels.

C K OSGOOD, C B FAVOUR.   

Abstract

The treatment with adrenocorticotropic hormone of guinea pigs sensitized with heat-killed tubercle bacilli caused suppression of their skin reactivity to tuberculin. Similar animals treated with saline did not show this change. Normal guinea pigs treated with adrenocorticotropic hormone showed suppression of inflammation, but not necrosis, produced by intracutaneous oil of turpentine. There was slight, but probably not significant, diminution of inflammation during saline administration. Tuberculin complement-fixing antibody titers were not altered by either adrenocorticotropic hormone or saline administration. Adrenocorticotropic hormone produced marked eosinopenia and lymphopenia in guinea pigs.

Entities:  

Keywords:  ACTH/effects; INFLAMMATION/experimental; TUBERCULIN; TURPENTINE

Mesh：

Substances：

Year:  1951        PMID： 14888823      PMCID： PMC2180331          DOI： 10.1084/jem.94.5.415

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  29 in total

1.  Treatment of typhoid fever. II. Control of clinical manifestations with cortisone.

Authors:  T E WOODWARD; H E HALL; R DIAS-RIVERA; J A HIGHTOWER; E MARTINEZ; R T PARKER
Journal:  Ann Intern Med       Date:  1951-01       Impact factor: 25.391

2.  Role of cortisone in regulation of inflammation.

Authors:  T F DOUGHERTY; G L SCHNEEBELI
Journal:  Proc Soc Exp Biol Med       Date:  1950-12

3.  Constitutional factors in resistance to infection; the effect of cortisone on the pathogenesis of tuberculosis.

Authors:  M B LURIE; P ZAPPASODI; A M DANNENBERG
Journal:  Science       Date:  1951-03-02       Impact factor: 47.728

4.  Response of tuberculin skin test to ACTH and cortisone in tuberculous guinea pigs.

Authors:  V J DERBES; J H DENT; N K WEAVER; D D VAUGHAN
Journal:  Proc Soc Exp Biol Med       Date:  1950-11

5.  Effect of ACTH and cortisone in experimental streptococcal and pneumococcal infections.

Authors:  R J GLASER; J W BERRY; L H LOEB; W B WOOD; W H DAUGHADAY
Journal:  J Lab Clin Med       Date:  1950-11

6.  Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit.

Authors:  F G GERMUTH; B OTTINGER
Journal:  Proc Soc Exp Biol Med       Date:  1950-08

7.  Enhancing effect of cortisone on tuberculosis in the mouse.

Authors:  P D'ARCY HART; R J W REES
Journal:  Lancet       Date:  1950-09-23       Impact factor: 79.321

8.  Effects of adrenocorticotropic hormone in pneumonia: clinical, bacteriological and serological studies.

Authors:  E H KASS; S H INGBAR; M FINLAND
Journal:  Ann Intern Med       Date:  1950-11       Impact factor: 25.391

9.  Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease.

Authors:  A C WOODS
Journal:  Am J Ophthalmol       Date:  1950-09       Impact factor: 5.258

10.  The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody.

Authors:  M BJØRNEBOE; E E FISCHEL; H C STOERK
Journal:  J Exp Med       Date:  1951-01       Impact factor: 14.307
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  3 in total

1.  In vitro studies of the cell-bound and antibody-mediated immunity evoked by murine renal allotransplants. Influence of presensitization, total body irradiation and immunosuppressive agents.

Authors:  B S Husberg
Journal:  Clin Exp Immunol       Date:  1973-06       Impact factor: 4.330

2.  [Tuberculin allergy in experimentally burned animals].

Authors:  W Vogel; O Haferkamp
Journal:  Virchows Arch Pathol Anat Physiol Klin Med       Date:  1967-06-12

3.  Delayed hypersensitivity. IV. Systemic reactivity of guinea pigs sensitized to protein antigens.

Authors:  J W UHR; M W BRANDRISS
Journal:  J Exp Med       Date:  1958-12-01       Impact factor: 14.307
  3 in total

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