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Literature DB >> 14870858

Microwaves in drug discovery and multi-step synthesis.

François-René Alexandre¹, Lisianne Domon, Stéphane Frère, Alexandra Testard, Valérie Thiéry, Thierry Besson.

Abstract

The interest of microwaves in drug discovery and multi-step synthesis is exposed with the aim of describing our strategy. These studies are connected with our work on the synthesis of original heterocyclic compounds with potential pharmaceutical value. Reactions in the presence of solvent and solvent-free synthesis can be realised under a variety of conditions; for some of these selected results are given, and where available, results from comparison with the same solvent-free conditions but with classical heating are given.

Entities: Disease

Mesh：

Substances：
Nitriles
Solvents
Carbon

Year: 2003 PMID： 14870858 DOI： 10.1023/b:modi.0000006860.56083.2b

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

2 in total

1. Synthesis and cytotoxic evaluation of novel thiazolocarbazoles.

Authors: Christelle Lamazzi; Hadjila Chabane; Valerie Thiery; Alain Pierre; Stephane Leonce; Bruno Pfeiffer; Pierre Renard; Gérald Guillaumet; Thierry Besson
Journal: J Enzyme Inhib Med Chem Date: 2002-12 Impact factor: 5.051

2. Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III.

Authors: Hadjila Chabane; Christelle Lamazzi; Valerie Thiery; Alain Pierre; Stephane Leonce; Bruno Pfeiffer; Pierre Renard; Gérald Guillaumet; Thierry Besson
Journal: J Enzyme Inhib Med Chem Date: 2003-04 Impact factor: 5.051

2 in total

4 in total

4. Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Authors: Damien Hédou; Carole Dubouilh-Benard; Nadège Loaëc; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal: Molecules Date: 2016-06-18 Impact factor: 4.411

4 in total

Microwaves in drug discovery and multi-step synthesis.

1. Synthesis and cytotoxic evaluation of novel thiazolocarbazoles.

2. Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III.

Review 1. Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

2. Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.

3. Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.

4. Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.