Literature DB >> 12683675

Synthesis and cytotoxic evaluation of novel thiazolocarbazoles.

Christelle Lamazzi1, Hadjila Chabane, Valerie Thiery, Alain Pierre, Stephane Leonce, Bruno Pfeiffer, Pierre Renard, Gérald Guillaumet, Thierry Besson.   

Abstract

Novel thiazolocarbazole derivatives 4 and 5 have been synthesized via the corresponding imino-1,2,3-dithiazoles 3. In vitro antitumor activity of these polyheterocyclic compounds was studied and the results show that 2-cyano derivatives exhibit a medium in vitro antiproliferative effect.

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Year:  2002        PMID： 12683675     DOI： 10.1080/1475636021000005703

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  3 in total

Review 1.  Microwaves in drug discovery and multi-step synthesis.

Authors:  François-René Alexandre; Lisianne Domon; Stéphane Frère; Alexandra Testard; Valérie Thiéry; Thierry Besson
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Authors:  Florence Couly; Marine Harari; Carole Dubouilh-Benard; Laetitia Bailly; Emilie Petit; Julien Diharce; Pascal Bonnet; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2018-08-29       Impact factor: 4.411

3.  Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Authors:  Damien Hédou; Carole Dubouilh-Benard; Nadège Loaëc; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2016-06-18       Impact factor: 4.411
  3 in total

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