Literature DB >> 14870844

A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines.

Núria Mont1, Jordi Teixidó, C Oliver Kappe, José I Borrell.   

Abstract

A high yield multicomponent reaction providing multifunctionalized pyrido[2,3-d]pyrimidines with up to four diversity centers in a one-pot microwave-assisted cyclocondensation of alpha,beta-unsaturated esters, amidine systems and malononitrile (or ethyl cyanoacetate) is described.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14870844     DOI： 10.1023/b:modi.0000006808.10647.f8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  7 in total

Review 1.  Multi-component reactions and evolutionary chemistry.

Authors:  Lutz Weber
Journal:  Drug Discov Today       Date:  2002-01-15       Impact factor: 7.851

2.  2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.

Authors:  A Gangjee; A Vasudevan; S F Queener; R L Kisliuk
Journal:  J Med Chem       Date:  1996-03-29       Impact factor: 7.446

3.  Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.

Authors:  A Gangjee; O Adair; S F Queener
Journal:  J Med Chem       Date:  1999-07-01       Impact factor: 7.446

4.  Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

Authors:  J I Borrell; J Teixidó; J L Matallana; B Martínez-Teipel; C Colominas; M Costa; M Balcells; E Schuler; M J Castillo
Journal:  J Med Chem       Date:  2001-07-05       Impact factor: 7.446

5.  Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.

Authors:  J M Hamby; C J Connolly; M C Schroeder; R T Winters; H D Showalter; R L Panek; T C Major; B Olsewski; M J Ryan; T Dahring; G H Lu; J Keiser; A Amar; C Shen; A J Kraker; V Slintak; J M Nelson; D W Fry; L Bradford; H Hallak; A M Doherty
Journal:  J Med Chem       Date:  1997-07-18       Impact factor: 7.446

Review 6.  Recent advances in isocyanide-based multicomponent chemistry.

Authors:  Alexander Dömling
Journal:  Curr Opin Chem Biol       Date:  2002-06       Impact factor: 8.822

7.  Pyrido[2, 3-d]pyrimidines and pyrimido[5',4':5, 6]pyrido[2, 3-d]pyrimidines as new antiviral agents: synthesis and biological activity.

Authors:  Magda N Nasr; Magdy M Gineinah
Journal:  Arch Pharm (Weinheim)       Date:  2002-06       Impact factor: 3.751
  7 in total
  4 in total

1.  Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines.

Authors:  Iñaki Galve; Raimon Puig de la Bellacasa; David Sánchez-García; Xavier Batllori; Jordi Teixidó; José I Borrell
Journal:  Mol Divers       Date:  2012-10-10       Impact factor: 2.943

2.  A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(₃Η,8Η)-diones.

Authors:  Marta Camarasa; Christian Barnils; Raimon Puig de la Bellacasa; Jordi Teixidó; José I Borrell
Journal:  Mol Divers       Date:  2013-05-26       Impact factor: 2.943

3.  A diversity oriented, microwave assisted synthesis of N-substituted 2-hydro-4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones.

Authors:  Núria Mont; Jordi Teixidó; José I Borrell
Journal:  Mol Divers       Date:  2008-11-27       Impact factor: 2.943

Review 4.  Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications.

Authors:  Guillem Jubete; Raimon Puig de la Bellacasa; Roger Estrada-Tejedor; Jordi Teixidó; José I Borrell
Journal:  Molecules       Date:  2019-11-16       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.