| Literature DB >> 1486610 |
R Karmali1, S N Schiffmann, J M Vanderwinden, G N Hendy, N Nys-DeWolf, J Corvilain, P Bergmann, J J Vanderhaeghen.
Abstract
Previous studies have indicated that 19-day-old fetal long bones of the rat contain an adenylyl cyclase-stimulating activity antigenically related to parathyroid hormone-related peptide. To ascertain its origin, Northern blotting and in situ hybridization histochemistry were performed. Results demonstrate that mRNA of parathyroid hormone-related peptide is present in RNA extracted from fetal long bones of the rat and that cells responsible for its production are localized in the periosteum. These cells are not mature osteoblasts because they do not synthesize mRNA of osteocalcin. Thus the present study shows that parathyroid hormone-related peptide could be produced locally, at least in part, in the skeleton of fetal rats.Entities:
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Year: 1992 PMID： 1486610 DOI： 10.1007/bf00645063
Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249