Literature DB >> 10475276

1,25-dihydroxyvitamin D3 inhibits parathyroid hormone-related peptide mRNA expression in fetal rat long bones in culture.

R Karmali1, N Nijs-De Wolf, I Beyer, G N Hendy, P Bergmann.   

Abstract

When fetal rat long bones are incubated in the presence of 10(-8) M 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], steady-state parathyroid hormone-related peptide (PTHrP) mRNA levels are decreased. This decrease is temporary: it is observed as soon as after 3 h of exposure and reaches a nadir after 6 h. At that time, PTHrP mRNA levels are significantly lower in the experimental than in the control bones. However the inhibitory effect vanishes after 24 h, despite continuous exposure to 1,25(OH)2D3 for even 48 h. This is the first report showing that PTHrP mRNA expression can be regulated in rat fetal long bones in vitro by 1,25(OH)2D3.

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Year:  1999        PMID： 10475276     DOI： 10.1007/s11626-999-0074-9

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol Anim        ISSN： 1071-2690            Impact factor:   2.416


  16 in total

1.  Adenylate cyclase stimulating activity immunologically similar to parathyroid hormone-related peptide can be extracted from fetal rat long bones.

Authors:  N Nijs-de Wolf; T Pepersack; J Corvilain; R Karmali; P Bergmann
Journal:  J Bone Miner Res       Date:  1991-09       Impact factor: 6.741

2.  Downregulation of the PTH/PTHrP receptor by vitamin D3 in the osteoblast-like ROS 17/2.8 cells.

Authors:  L Y Xie; A Leung; G V Segre; I Yamamoto; A B Abou-Samra
Journal:  Am J Physiol       Date:  1996-04

3.  Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture.

Authors:  L G Raisz; I Niemann
Journal:  Endocrinology       Date:  1969-09       Impact factor: 4.736

4.  The noncalcemic vitamin D analogues EB1089 and 22-oxacalcitriol interact with the vitamin D receptor and suppress parathyroid hormone-related peptide gene expression.

Authors:  M Falzon
Journal:  Mol Cell Endocrinol       Date:  1997-03-14       Impact factor: 4.102

5.  Temporal expression of PTHrP during endochondral bone formation in mouse and intramembranous bone formation in an in vivo rabbit model.

Authors:  V Kartsogiannis; J Moseley; B McKelvie; S T Chou; D K Hards; K W Ng; T J Martin; H Zhou
Journal:  Bone       Date:  1997-11       Impact factor: 4.398

6.  Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene.

Authors:  R Kremer; M Sebag; C Champigny; K Meerovitch; G N Hendy; J White; D Goltzman
Journal:  J Biol Chem       Date:  1996-07-05       Impact factor: 5.157

7.  Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.

Authors:  K Lee; J D Deeds; G V Segre
Journal:  Endocrinology       Date:  1995-02       Impact factor: 4.736

8.  Expression of mRNA of parathyroid hormone-related peptide in fetal bones of the rat.

Authors:  R Karmali; S N Schiffmann; J M Vanderwinden; G N Hendy; N Nys-DeWolf; J Corvilain; P Bergmann; J J Vanderhaeghen
Journal:  Cell Tissue Res       Date:  1992-12       Impact factor: 5.249

9.  Evidence for the uptake of a vitamin D analogue (OCT) by a human carcinoma and its effect of suppressing the transcription of parathyroid hormone-related peptide gene in vivo.

Authors:  K Endo; F Ichikawa; Y Uchiyama; K Katsumata; H Ohkawa; K Kumaki; E Ogata; K Ikeda
Journal:  J Biol Chem       Date:  1994-12-23       Impact factor: 5.157

10.  Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion.

Authors:  R Kremer; A C Karaplis; J Henderson; W Gulliver; D Banville; G N Hendy; D Goltzman
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808
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  1 in total

1.  1,25-Dihydroxyvitamin D(3) regulates PTHrP expression via transcriptional, post-transcriptional and post-translational pathways.

Authors:  Vandanajay Bhatia; Ramanjaneya V Mula; Miriam Falzon
Journal:  Mol Cell Endocrinol       Date:  2011-06-01       Impact factor: 4.102
  1 in total

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