Literature DB >> 1486331

Structure and expression of the human insulin-like growth factor genes.

J S Sussenbach1, P H Steenbergh, P Holthuizen.   

Abstract

The human insulin-like growth factors (IGFs) are important regulators of growth, which exert their functions via endocrine, paracrine and autocrine mechanisms of action. Structural analysis of the genes coding for IGF-I and -II has revealed that they have a complex exon-intron structure and possess multiple promoters. The expression of the IGF genes is regulated at the levels of transcription, RNA processing and translation. This review summarizes our current knowledge of the structure and expression of these genes.

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Year:  1992        PMID： 1486331

Source DB:  PubMed          Journal:  Growth Regul        ISSN： 0956-523X


  20 in total

Review 1.  A systematic analysis of disease-associated variants in the 3' regulatory regions of human protein-coding genes I: general principles and overview.

Authors:  Jian-Min Chen; Claude Férec; David N Cooper
Journal:  Hum Genet       Date:  2006-04-28       Impact factor: 4.132

2.  IGF-II dependent autocrine growth in cell lines derived from renal tumours of childhood.

Authors:  W Zumkeller; A Mahmood; R Dellow; P N Schofield
Journal:  Clin Mol Pathol       Date:  1995-12

3.  Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment.

Authors:  Taichi Kimura; Takeshi Kuwata; Satoshi Ashimine; Manabu Yamazaki; Chisako Yamauchi; Kanji Nagai; Akashi Ikehara; Yang Feng; Dimiter S Dimitrov; Seiichi Saito; Atsushi Ochiai
Journal:  Clin Cancer Res       Date:  2009-12-22       Impact factor: 12.531

Review 4.  Targeting the insulin-like growth factor pathway in hepatocellular carcinoma.

Authors:  Mónica Enguita-Germán; Puri Fortes
Journal:  World J Hepatol       Date:  2014-10-27

5.  The insulin-like growth factor 2 gene and locus in nonmammalian vertebrates: Organizational simplicity with duplication but limited divergence in fish.

Authors:  Peter Rotwein
Journal:  J Biol Chem       Date:  2018-08-28       Impact factor: 5.157

6.  Proteins binding to the leader of the 6.0 kb mRNA of human insulin-like growth factor 2 influence translation.

Authors:  C H de Moor; M Jansen; E J Bonte; A A Thomas; J S Sussenbach; J L Van Den Brande
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

7.  Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

Authors:  J Zapf; E Futo; M Peter; E R Froesch
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

8.  Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I.

Authors:  Lisbeth Gauguin; Carlie Delaine; Clair L Alvino; Kerrie A McNeil; John C Wallace; Briony E Forbes; Pierre De Meyts
Journal:  J Biol Chem       Date:  2008-05-23       Impact factor: 5.157

9.  Translation initiation on the insulin-like growth factor II leader 1 is developmentally regulated.

Authors:  H Teerink; M A Kasperaitis; C H De Moor; H O Voorma; A A Thomas
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

10.  Similarity and variation in the insulin-like growth factor 2 - H19 locus in primates.

Authors:  Peter Rotwein
Journal:  Physiol Genomics       Date:  2018-03-30       Impact factor: 3.107
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