| Literature DB >> 14861374 |
J CASALS, P K OLITSKY, R O ANSLOW.
Abstract
A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.Entities:
Keywords: POLIOMYELITIS
Mesh:
Substances:
Year: 1951 PMID: 14861374 PMCID: PMC2136099 DOI: 10.1084/jem.94.2.123
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307