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Literature DB >> 1483927

Oligonucleotide sequences required for natural killer cell activation.

E Kuramoto¹, O Yano, Y Kimura, M Baba, T Makino, S Yamamoto, T Yamamoto, T Kataoka, T Tokunaga.

Abstract

Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. The results indicated that the activity depended critically on the presence of particular palindromic sequences including the 5'-CG-3' motif(s). The size and the number of palindromes as well as the extra-palindromic sequences also influenced the activity. An oligonucleotide with a 10-mer palindrome and extra-palindromic oligoguanylate sequences showed the strongest activity among the oligonucleotides tested.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Oligonucleotides

Year: 1992 PMID： 1483927 PMCID： PMC5918715 DOI： 10.1111/j.1349-7006.1992.tb02734.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

14 in total

1. Selection of single-stranded DNA molecules that bind and inhibit human thrombin.

Authors: L C Bock; L C Griffin; J A Latham; E H Vermaas; J J Toole
Journal: Nature Date: 1992-02-06 Impact factor: 49.962

2. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.

Authors: S Shimada; O Yano; T Tokunaga
Journal: Jpn J Cancer Res Date: 1986-08

3. An optimized potential function for the calculation of nucleic acid interaction energies I. base stacking.

Authors: R L Ornstein; R Rein
Journal: Biopolymers Date: 1978-10 Impact factor: 2.505

4. Improved estimation of secondary structure in ribonucleic acids.

Authors: I Tinoco; P N Borer; B Dengler; M D Levin; O C Uhlenbeck; D M Crothers; J Bralla
Journal: Nat New Biol Date: 1973-11-14

5. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth.

Authors: S Yamamoto; T Yamamoto; S Shimada; E Kuramoto; O Yano; T Kataoka; T Tokunaga
Journal: Microbiol Immunol Date: 1992 Impact factor: 1.955

6. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

Authors: S Yamamoto; T Yamamoto; T Kataoka; E Kuramoto; O Yano; T Tokunaga
Journal: J Immunol Date: 1992-06-15 Impact factor: 5.422

7. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.

Authors: S Shimada; O Yano; H Inoue; E Kuramoto; T Fukuda; H Yamamoto; T Kataoka; T Tokunaga
Journal: J Natl Cancer Inst Date: 1985-03 Impact factor: 13.506

8. A proton nuclear-magnetic-resonance study of self-stacking in purine and pyrimidine nucleosides and nucleotides.

Authors: P R Mitchell; H Sigel
Journal: Eur J Biochem Date: 1978-07-17

9. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.

Authors: T Tokunaga; H Yamamoto; S Shimada; H Abe; T Fukuda; Y Fujisawa; Y Furutani; O Yano; T Kataoka; T Sudo
Journal: J Natl Cancer Inst Date: 1984-04 Impact factor: 13.506

10. Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG.

Authors: T Kataoka; S Yamamoto; T Yamamoto; E Kuramoto; Y Kimura; O Yano; T Tokunaga
Journal: Jpn J Cancer Res Date: 1992-03

22 in total

Oligonucleotide sequences required for natural killer cell activation.

1. Selection of single-stranded DNA molecules that bind and inhibit human thrombin.

2. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.

3. An optimized potential function for the calculation of nucleic acid interaction energies I. base stacking.

4. Improved estimation of secondary structure in ribonucleic acids.

5. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth.

6. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

7. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.

8. A proton nuclear-magnetic-resonance study of self-stacking in purine and pyrimidine nucleosides and nucleotides.

9. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.

10. Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG.

Review 1. Signal transduction induced by immunostimulatory CpG DNA.

Review 2. Introduction to immunostimulatory DNA sequences.

Review 3. Mechanisms of immune stimulation by bacterial DNA.

Review 4. Activation of NK cell (human and mouse) by immunostimulatory DNA sequence.

5. Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.

6. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract.

7. Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle.

8. CpG motifs in Porphyromonas gingivalis DNA stimulate interleukin-6 expression in human gingival fibroblasts.

Review 9. Synthetic oligonucleotides: useful molecules? A review.

10. Expression of Toll-like receptor 9 in mouse and human lungs.