Literature DB >> 1480349

Chronic mild stress-induced anhedonia: a realistic animal model of depression.

P Willner1, R Muscat, M Papp.   

Abstract

Chronic sequential administration of a variety of mild stressors causes a decrease in responsiveness to rewards in rats, which is reversed by chronic administration of antidepressant drugs. This paper reviews the validity of chronic mild stress-induced anhedonia as an animal model of depression, and the evidence that changes in hedonic responsiveness in this model are mediated by changes in the sensitivity of dopamine D2 receptors in the nucleus accumbens. The review opens with an analysis of the design features of animal models of depression, and ends with a brief account of other animal models of anhedonia.

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Year:  1992        PMID: 1480349     DOI: 10.1016/s0149-7634(05)80194-0

Source DB:  PubMed          Journal:  Neurosci Biobehav Rev        ISSN: 0149-7634            Impact factor:   8.989


  278 in total

1.  Prophylactic actions of the antioxidant agent AEKOL on behavioral (psychoemotional) disturbances induced by chronic stress in rats.

Authors:  M A Kulikov
Journal:  Neurosci Behav Physiol       Date:  2001 Sep-Oct

Review 2.  Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.

Authors:  Marcello Leopoldo; Enza Lacivita; Francesco Berardi; Roberto Perrone; Peter B Hedlund
Journal:  Pharmacol Ther       Date:  2010-10-20       Impact factor: 12.310

3.  cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress.

Authors:  Yanyong Liu; Nan Yang; Pingping Zuo
Journal:  Cell Mol Neurobiol       Date:  2010-06-09       Impact factor: 5.046

4.  Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat.

Authors:  Brittney M Cox; Fares Alsawah; Peter C McNeill; Matthew P Galloway; Shane A Perrine
Journal:  Behav Brain Res       Date:  2011-01-28       Impact factor: 3.332

Review 5.  Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

Authors:  Rita Z Goldstein; Nora D Volkow
Journal:  Am J Psychiatry       Date:  2002-10       Impact factor: 18.112

6.  Oxidative parameters in the rat brain of chronic mild stress model for depression: relation to anhedonia-like responses.

Authors:  Chao Wang; He-Ming Wu; Xiao-Rong Jing; Qiang Meng; Bei Liu; Hua Zhang; Guo-Dong Gao
Journal:  J Membr Biol       Date:  2012-07-08       Impact factor: 1.843

Review 7.  Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications.

Authors:  Julienne E Bower; Donald M Lamkin
Journal:  Brain Behav Immun       Date:  2012-07-06       Impact factor: 7.217

8.  Enhanced Hypothalamic NMDA Receptor Activity Contributes to Hyperactivity of HPA Axis in Chronic Stress in Male Rats.

Authors:  Jing-Jing Zhou; Yonggang Gao; Xiangjian Zhang; Therese A Kosten; De-Pei Li
Journal:  Endocrinology       Date:  2018-03-01       Impact factor: 4.736

9.  Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression.

Authors:  Roee Admon; Laura M Holsen; Harlyn Aizley; Anne Remington; Susan Whitfield-Gabrieli; Jill M Goldstein; Diego A Pizzagalli
Journal:  Biol Psychiatry       Date:  2014-10-02       Impact factor: 13.382

10.  Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress.

Authors:  Gaurav Patki; Naimesh Solanki; Fatin Atrooz; Farida Allam; Samina Salim
Journal:  Brain Res       Date:  2013-10-03       Impact factor: 3.252

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