Literature DB >> 1479882

Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins.

K Aktories1, A Wegner.   

Abstract

Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin, and Clostridium spiroforme toxin ADP-ribosylate actin monomers. Toxin-induced ADP-ribosylation disturbs the cellular equilibrium between monomeric and polymeric actin and traps monomeric actin in its unpolymerized form, thereby depolymerizing actin filaments and destroying the microfilament network. Furthermore, the toxins ADP-ribosylate gelsolin actin complexes. These modifications may contribute to the cytopathic action of the toxins.

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Year:  1992        PMID： 1479882     DOI： 10.1111/j.1365-2958.1992.tb01749.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  26 in total

1.  The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding.

Authors:  D Blöcker; H Barth; E Maier; R Benz; J T Barbieri; K Aktories
Journal:  Infect Immun       Date:  2000-08       Impact factor: 3.441

2.  Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.

Authors:  D K Meyer; C Olenik; F Hofmann; H Barth; J Leemhuis; I Brünig; K Aktories; W Nörenberg
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

Review 3.  Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.

Authors:  Alexander E Lang; Gudula Schmidt; Joel J Sheets; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-11-12       Impact factor: 3.000

4.  Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization.

Authors:  M Palmer; R Harris; C Freytag; M Kehoe; J Tranum-Jensen; S Bhakdi
Journal:  EMBO J       Date:  1998-03-16       Impact factor: 11.598

Review 5.  Clostridial enteric diseases of domestic animals.

Authors:  J G Songer
Journal:  Clin Microbiol Rev       Date:  1996-04       Impact factor: 26.132

6.  Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex.

Authors:  Toshiharu Tsurumura; Yayoi Tsumori; Hao Qiu; Masataka Oda; Jun Sakurai; Masahiro Nagahama; Hideaki Tsuge
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

7.  Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin.

Authors:  G Kiefer; M Lerner; P Sehr; I Just; K Aktories
Journal:  Med Microbiol Immunol       Date:  1996-02       Impact factor: 3.402

Review 8.  Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.

Authors:  K Aktories
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

9.  Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.

Authors:  Carina Gonçalves; Dominique Decré; Frédéric Barbut; Béatrice Burghoffer; Jean-Claude Petit
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

10.  Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.

Authors:  Carsten Schwan; Bärbel Stecher; Tina Tzivelekidis; Marco van Ham; Manfred Rohde; Wolf-Dietrich Hardt; Jürgen Wehland; Klaus Aktories
Journal:  PLoS Pathog       Date:  2009-10-16       Impact factor: 6.823
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