Literature DB >> 1479377

A colorimetric microassay for the detection of agents that interact with DNA.

N S Burres1, A Frigo, R R Rasmussen, J B McAlpine.   

Abstract

A simple microtiter assay for the detection of compounds that bind DNA is described. Agents that displace methyl green from DNA are detected spectrophotometrically by a decrease in absorbance at 630 nm. The feasibility of using the assay for detecting DNA-active compounds in fermentation extracts was assessed, and the activities of reference compounds in the methyl green assay and an ethidium bromide displacement method were compared.

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Year:  1992        PMID： 1479377     DOI： 10.1021/np50089a004

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Synthesis, characterization, antibacterial evaluation, 2D-QSAR modeling and molecular docking studies for benzocaine derivatives.

Authors:  Israa Taha; Eman M Keshk; Abdel-Galil M Khalil; Ahmed Fekri
Journal:  Mol Divers       Date:  2020-09-25       Impact factor: 2.943

2.  Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles.

Authors:  Jaroslav Malina; Hana Kostrhunova; Vojtech Novohradsky; Peter Scott; Viktor Brabec
Journal:  Nucleic Acids Res       Date:  2022-01-25       Impact factor: 16.971

3.  Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies.

Authors:  Mohamed M Khalifa; Ahmed A Al-Karmalawy; Eslam B Elkaeed; Mohamed S Nafie; Mohamed A Tantawy; Ibrahim H Eissa; Hazem A Mahdy
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

4.  Design of peptides interfering with iron-dependent regulator (IdeR) and evaluation of Mycobacterium tuberculosis growth inhibition.

Authors:  Himen Salimizand; Saeid Amel Jamehdar; Leila Babaei Nik; Hamid Sadeghian
Journal:  Iran J Basic Med Sci       Date:  2017-06       Impact factor: 2.699
  4 in total

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