D Howard1, D F Thompson. 1. College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73117.
Abstract
OBJECTIVE: To review the evidence that taurine can prevent cholestasis in neonates. DATA SOURCES: MEDLINE and EMBASE searches were conducted to identify both animal and human data regarding taurine's role in bile acid conjugation and liver disease (key terms: taurine, children less than two years old). STUDY SELECTION: Emphasis was placed on human data supplemented by relevant animal data. DATA SYNTHESIS: Taurine appears to more effectively conjugate bile acids than glycine, and the end-products of conjugation are more soluble. Taurine deficiency may increase glyco-conjugates of bile acids and result in cholestasis. Although the cause of neonatal cholestasis probably is multifactorial, there are data indicating that adequate taurine may prevent cholestasis in neonates. CONCLUSIONS: Taurine should be considered an essential amino acid for neonates and should be included in total parenteral nutrition solutions for these patients.
OBJECTIVE: To review the evidence that taurine can prevent cholestasis in neonates. DATA SOURCES: MEDLINE and EMBASE searches were conducted to identify both animal and human data regarding taurine's role in bile acid conjugation and liver disease (key terms: taurine, children less than two years old). STUDY SELECTION: Emphasis was placed on human data supplemented by relevant animal data. DATA SYNTHESIS: Taurine appears to more effectively conjugate bile acids than glycine, and the end-products of conjugation are more soluble. Taurine deficiency may increase glyco-conjugates of bile acids and result in cholestasis. Although the cause of neonatal cholestasis probably is multifactorial, there are data indicating that adequate taurine may prevent cholestasis in neonates. CONCLUSIONS:Taurine should be considered an essential amino acid for neonates and should be included in total parenteral nutrition solutions for these patients.
Authors: Kara L Calkins; Lauren A Sanchez; Chi-Hong Tseng; Kym F Faull; Alexander J Yoon; Christopher M Ryan; Thuc Le; Stephen B Shew Journal: JPEN J Parenter Enteral Nutr Date: 2014-08-19 Impact factor: 4.016