Literature DB >> 14769245

Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives.

Sushilkumar S Bahekar1, Devanand B Shinde.   

Abstract

Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.

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Year:  2003        PMID： 14769245

Source DB:  PubMed          Journal:  Acta Pharm        ISSN： 1330-0075            Impact factor:   2.230


  6 in total

1.  Novel dihydropyrimidine derivatives as potential HDAC inhibitors: in silico study.

Authors:  Ganapathi Thipparapu; Rajanna Ajumeera; Vijayalakshmi Venkatesan
Journal:  In Silico Pharmacol       Date:  2017-10-12

2.  Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors.

Authors:  Deepak Lokwani; Reecha Shah; Santosh Mokale; Padma Shastry; Devanand Shinde
Journal:  J Comput Aided Mol Des       Date:  2012-01-05       Impact factor: 3.686

3.  1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study.

Authors:  Katharigatta N Venugopala; Pottathil Shinu; Christophe Tratrat; Pran Kishore Deb; Raquel M Gleiser; Sandeep Chandrashekharappa; Deepak Chopra; Mahesh Attimarad; Anroop B Nair; Nagaraja Sreeharsha; Fawzi M Mahomoodally; Michelyne Haroun; Mahmoud Kandeel; Syed Mohammed Basheeruddin Asdaq; Viresh Mohanlall; Nizar A Al-Shar'i; Mohamed A Morsy
Journal:  Molecules       Date:  2022-04-21       Impact factor: 4.927

4.  Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis.

Authors:  Katharigatta N Venugopala; G B Dharma Rao; Subhrajyoti Bhandary; Melendhran Pillay; Deepak Chopra; Bandar E Aldhubiab; Mahesh Attimarad; Osama Ibrahim Alwassil; Sree Harsha; Koleka Mlisana
Journal:  Drug Des Devel Ther       Date:  2016-08-25       Impact factor: 4.162

5.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

6.  In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.

Authors:  Katharigatta N Venugopala; Christophe Tratrat; Melendhran Pillay; Sandeep Chandrashekharappa; Omar Husham Ahmed Al-Attraqchi; Bandar E Aldhubiab; Mahesh Attimarad; Osama I Alwassil; Anroop B Nair; Nagaraja Sreeharsha; Rashmi Venugopala; Mohamed A Morsy; Michelyne Haroun; Hezekiel M Kumalo; Bharti Odhav; Koleka Mlisana
Journal:  Drug Des Devel Ther       Date:  2020-03-09       Impact factor: 4.162
  6 in total

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