Literature DB >> 14767079

The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila.

Moses Makokha1, Yuanpeng Janet Huang, Gaetano Montelione, Arthur S Edison, Elisar Barbar.   

Abstract

The structure of Drosophila LC8 pH-induced monomer has been determined by NMR spectroscopy using the program AutoStructure. The structure at pH 3 and 30 degrees C is similar to the individual subunits of mammalian LC8 dimer with the exception that a beta strand, which crosses between monomers to form an intersubunit beta-sheet in the dimer, is a flexible loop with turnlike conformations in the monomer. Increased flexibility in the interface region relative to the rest of the protein is confirmed by dynamic measurements based on (15)N relaxation. Comparison of the monomer and dimer structures indicates that LC8 is not a domain swapped dimer.

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Year:  2004        PMID： 14767079      PMCID： PMC2286742          DOI： 10.1110/ps.03462204

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  32 in total

1.  Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain.

Authors:  J Fan; Q Zhang; H Tochio; M Li; M Zhang
Journal:  J Mol Biol       Date:  2001-02-09       Impact factor: 5.469

2.  Interaction of the rabies virus P protein with the LC8 dynein light chain.

Authors:  H Raux; A Flamand; D Blondel
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

3.  Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation.

Authors:  Jane S Richardson; David C Richardson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-05       Impact factor: 11.205

4.  Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric protein.

Authors:  N J Greenfield; Y J Huang; T Palm; G V Swapna; D Monleon; G T Montelione; S E Hitchcock-DeGregori
Journal:  J Mol Biol       Date:  2001-09-28       Impact factor: 5.469

5.  NMR-detected order in core residues of denatured bovine pancreatic trypsin inhibitor.

Authors:  E Barbar; M Hare; M Makokha; G Barany; C Woodward
Journal:  Biochemistry       Date:  2001-08-14       Impact factor: 3.162

6.  The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN.

Authors:  F S Espindola; D M Suter; L B Partata; T Cao; J S Wolenski; R E Cheney; S M King; M S Mooseker
Journal:  Cell Motil Cytoskeleton       Date:  2000-12

7.  Dimerization and folding of LC8, a highly conserved light chain of cytoplasmic dynein.

Authors:  E Barbar; B Kleinman; D Imhoff; M Li; T S Hays; M Hare
Journal:  Biochemistry       Date:  2001-02-13       Impact factor: 3.162

8.  Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74.

Authors:  Moses Makokha; Michael Hare; Mingang Li; Thomas Hays; Elisar Barbar
Journal:  Biochemistry       Date:  2002-04-02       Impact factor: 3.162

9.  Solution NMR structure of ribosome-binding factor A (RbfA), a cold-shock adaptation protein from Escherichia coli.

Authors:  Yuanpeng Janet Huang; G V T Swapna; P K Rajan; Haiping Ke; Bing Xia; Kamal Shukla; Masayori Inouye; Gaetano T Montelione
Journal:  J Mol Biol       Date:  2003-03-21       Impact factor: 5.469

10.  Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.

Authors:  S Naisbitt; J Valtschanoff; D W Allison; C Sala; E Kim; A M Craig; R J Weinberg; M Sheng
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167
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  13 in total

1.  Structural dynamics and multiregion interactions in dynein-dynactin recognition.

Authors:  Jessica L Morgan; Yujuan Song; Elisar Barbar
Journal:  J Biol Chem       Date:  2011-09-19       Impact factor: 5.157

2.  pH driven conformational dynamics and dimer-to-monomer transition in DLC8.

Authors:  P M Krishna Mohan; Maneesha Barve; Amarnath Chatterjee; Ramakrishna V Hosur
Journal:  Protein Sci       Date:  2005-12-29       Impact factor: 6.725

3.  Folding is coupled to dimerization of Tctex-1 dynein light chain.

Authors:  Matthew Talbott; Michael Hare; Afua Nyarko; Thomas S Hays; Elisar Barbar
Journal:  Biochemistry       Date:  2006-06-06       Impact factor: 3.162

Review 4.  Structure-function-folding relationships and native energy landscape of dynein light chain protein: nuclear magnetic resonance insights.

Authors:  P M Krishna Mohan; Ramakrishna V Hosur
Journal:  J Biosci       Date:  2009-09       Impact factor: 1.826

5.  Dynein light chain 1 (LC8) association enhances microtubule stability and promotes microtubule bundling.

Authors:  Jayant Asthana; Anuradha Kuchibhatla; Swadhin Chandra Jana; Krishanu Ray; Dulal Panda
Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157

Review 6.  Structural atlas of dynein motors at atomic resolution.

Authors:  Akiyuki Toda; Hideaki Tanaka; Genji Kurisu
Journal:  Biophys Rev       Date:  2018-02-24

7.  Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.

Authors:  László Radnai; Péter Rapali; Zsuzsa Hódi; Dániel Süveges; Tamás Molnár; Bence Kiss; Bálint Bécsi; Ferenc Erdödi; László Buday; József Kardos; Mihály Kovács; László Nyitray
Journal:  J Biol Chem       Date:  2010-10-02       Impact factor: 5.157

8.  Resonance Assignments and Secondary Structure Analysis of Dynein Light Chain 8 by Magic Angle Spinning NMR Spectroscopy.

Authors:  Shangjin Sun; Andrew H Butterworth; Sivakumar Paramasivam; Si Yan; Christine M Lightcap; John C Williams; Tatyana Polenova
Journal:  Can J Chem       Date:  2011-08-04       Impact factor: 1.118

9.  Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation.

Authors:  Pablo Gallego; Adrian Velazquez-Campoy; Laura Regué; Joan Roig; David Reverter
Journal:  J Biol Chem       Date:  2013-03-12       Impact factor: 5.157

10.  Structural, thermodynamic, and kinetic effects of a phosphomimetic mutation in dynein light chain LC8.

Authors:  Gregory Benison; Marcus Chiodo; P Andrew Karplus; Elisar Barbar
Journal:  Biochemistry       Date:  2009-12-08       Impact factor: 3.162
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